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Stock-based Compensation Plans (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-Based Payment Arrangement [Abstract] |
Summary of Stock Option Activity | The following table summarizes stock option activity for the twelve months ended December 31, 2022 and 2021 under the 2019 Plan:
| Options |  | Weighted- Average Exercise Price |  | Weighted- Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value
Outstanding as of January 1, 2022 | 2,157,460 |  |  | $ | 13.54 |  |  |  |  |
Granted | 1,886,263 |  |  | $ | 8.73 |  |  |  |  |
Exercised | (852) |  |  | $ | 5.67 |  |  |  |  |
Forfeited or expired | (251,183) |  |  | $ | 10.79 |  |  |  |  |
Outstanding as of December 31, 2022 | 3,791,688 |  |  | $ | 11.33 |  |  | 8.35 |  | $ | 375 |
Options vested and expected to vest as of December 31, 2022 | 3,791,688 |  |  | $ | 11.33 |  |  | 8.35 |  | $ | 375 |
Options exercisable as of December 31, 2022 | 1,398,490 |  |  | $ | 13.33 |  |  | 7.50 |  | $ | — |
| Options |  | Weighted- Average Exercise Price |  | Weighted- Average Remaining Contractual Term (Years) |  | Aggregate Intrinsic Value
Outstanding as of January 1, 2021 | 1,117,160 |  |  | $ | 12.96 |  |  |  |  |
Granted | 1,193,809 |  |  | $ | 14.08 |  |  |  |  |
Exercised | — |  |  | $ | — |  |  |  |  |
Forfeited or expired | (153,509) |  |  | $ | 13.50 |  |  |  |  |
Outstanding as of December 31, 2021 | 2,157,460 |  |  | $ | 13.54 |  |  | 8.74 |  | $ | 302,155 |
Options vested and expected to vest as of December 31, 2021 | 2,157,460 |  |  | $ | 13.54 |  |  | 8.74 |  | $ | 302,155 |
Options exercisable as of December 31, 2021 | 752,954 |  |  | $ | 13.48 |  |  | 8.15 |  | $ | 79,431 |
Schedule of Valuation Assumptions Used | The following are the underlying assumptions used in the Black-Scholes-Merton option pricing model to determine the fair value of stock options granted to employees and to non-employees under this stock plan:
| 2022 | 2021
Risk-free interest rate | 2.09% | 0.93%
Expected dividend yield | 0% | 0%
Expected volatility | 97.8% | 93.0%
Expected term of options (years) | 6.0 | 6.0
Schedule of Stock-based Compensation Expense for Stock Awards Recognized | Total stock-based compensation expense for all stock awards recognized in the accompanying audited consolidated statements of operations is as follows (in thousands):
| Year Ended December 31,
| 2022 |  | 2021
Research and development | $ | 3,219 |  |  | $ | 1,760 |
General and administrative | 4,710 |  |  | 4,189 |
Total | $ | 7,929 |  |  | $ | 5,949 |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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