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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Cash flows from operating activities:    
Net loss $ (120,407) $ (92,945)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 77 85
Goodwill impairment (see Note 2) 32,970 0
Stock-based compensation 7,929 5,949
Foreign currency loss 4,757 4,332
Common stock issued in connection with the 4SC royalty settlement (see Note 4) 0 8,625
Changes in operating assets and liabilities:    
Prepaid expenses and other assets 7,493 (12,800)
Accounts payable 799 176
Other liabilities (124) 170
Accrued expenses and other current liabilities 1,362 3,175
Net cash used in operating activities (65,144) (83,233)
Cash flows from investing activities:    
Purchases of Investments-other (9,629) 0
Purchases of property and equipment (112) (67)
Net cash used in investing activities (9,741) (67)
Cash flows from financing activities:    
Proceeds from the exercise of stock options 5 0
Proceeds from shares issued in connection with the Company's employee stock purchase plan 182 92
Net cash provided by financing activities 95,760 42,841
Effect of exchange rate changes on cash and cash equivalents (993) (130)
Net change in cash and cash equivalents 19,882 (40,589)
Cash and cash equivalents, beginning of year 86,863 127,452
Cash and cash equivalents, end of year 106,745 86,863
Supplemental disclosure of noncash investing and financing activities:    
Common stock issued in connection with the 4SC royalty settlement (see Note 4) 0 8,625
Operating lease right-of use asset obtained in exchange for lease obligation 974 435
Public Offering    
Cash flows from financing activities:    
Proceeds from issuance of common stock 39,584 729
October 2022 PIPE Transaction    
Cash flows from financing activities:    
Proceeds from issuance of common stock 55,989 0
July 2021 Public Equity Offering    
Cash flows from financing activities:    
Proceeds from issuance of common stock $ 0 $ 42,020