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Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | October 2022 PIPE Transaction | At The Market Sales Agreement | 4SC Royalty Settlement | Common Stock | Common Stock October 2022 PIPE Transaction | Common Stock At The Market Sales Agreement | Common Stock 4SC Royalty Settlement | Additional Paid-in Capital | Additional Paid-in Capital October 2022 PIPE Transaction | Additional Paid-in Capital At The Market Sales Agreement | Additional Paid-in Capital 4SC Royalty Settlement | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2021 |  |  |  |  | 26,335,418 |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2021 | $ 127,115 |  |  |  | $ 3 |  |  |  | $ 324,237 |  |  |  | $ (252) | $ (196,873)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (120,407) |  |  |  |  |  |  |  |  |  |  |  |  | (120,407)
Foreign exchange translation adjustment | 3,287 |  |  |  |  |  |  |  |  |  |  |  | 3,287 |
Stock-based compensation | 7,929 |  |  |  |  |  |  |  | 7,929 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  | 8,696,552 | 4,204,113 | 852 |  |  |  |  |  |
Issuance of common stock |  | $ 55,989 | $ 39,584 | $ 5 |  | $ 1 |  |  |  | $ 55,988 | $ 39,584 | $ 5 |  |
Shares issued in connection with the Company's employee stock purchase plan (in shares) |  |  |  |  | 70,351 |  |  |  |  |  |  |  |  |
Shares issued in connection with the Company's employee stock purchase plan | $ 182 |  |  |  |  |  |  |  | 182 |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2022 | 39,307,286 |  |  |  | 39,307,286 |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 113,684 |  |  |  | $ 4 |  |  |  | 427,925 |  |  |  | 3,035 | (317,280)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |
Net loss | (93,612) |  |  |  |  |  |  |  |  |  |  |  |  | (93,612)
Foreign exchange translation adjustment | 724 |  |  |  |  |  |  |  |  |  |  |  | 724 |
Stock-based compensation | 7,102 |  |  |  |  |  |  |  | 7,102 |  |  |  |  |
Issuance of common stock (in shares) |  |  |  |  |  |  | 657,012 |  |  |  |  |  |  |
Issuance of common stock |  |  | $ 853 |  |  |  |  |  |  |  | $ 853 |  |  |
Shares issued from exercise of pre-funded warrants (in shares) |  |  |  |  | 5,096,552 |  |  |  |  |  |  |  |  |
Shares issued from exercise of pre-funded warrants | 51 |  |  |  |  |  |  |  | 51 |  |  |  |  |
Shares issued in connection with the Company's employee stock purchase plan (in shares) |  |  |  |  | 116,880 |  |  |  |  |  |  |  |  |
Shares issued in connection with the Company's employee stock purchase plan | $ 129 |  |  |  |  |  |  |  | 129 |  |  |  |  |
Ending balance (in shares) at Dec. 31, 2023 | 45,177,730 |  |  |  | 45,177,730 |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2023 | $ 28,931 |  |  |  | $ 4 |  |  |  | $ 436,060 |  |  |  | $ 3,759 | $ (410,892)

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