-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 JdGfX2NrVp3cG0q+qqGKjV0O93tkqzyFp4IcDvtoKilxnGLwbZ6x5ORROghQL8Qn
 xLO2kbbEJ1agFEDWBTPOrw==

<SEC-DOCUMENT>0001116354-10-000001.txt : 20100105
<SEC-HEADER>0001116354-10-000001.hdr.sgml : 20100105
<ACCEPTANCE-DATETIME>20100105140156
ACCESSION NUMBER:		0001116354-10-000001
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20100105
DATE AS OF CHANGE:		20100105
EFFECTIVENESS DATE:		20100105

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CHAMPIONS BIOTECHNOLOGY, INC.
		CENTRAL INDEX KEY:			0000771856
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				521401755
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0430

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-77185-6A
		FILM NUMBER:		10505783

	BUSINESS ADDRESS:	
		STREET 1:		855 N. WOLFE STREET
		STREET 2:		SUITE 619
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21205
		BUSINESS PHONE:		410-369-0365

	MAIL ADDRESS:	
		STREET 1:		855 N. WOLFE STREET
		STREET 2:		SUITE 619
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21205

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CHAMPIONS SPORTS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INTERNATIONAL GROUP INC
		DATE OF NAME CHANGE:	19860319
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000771856</cik>
        <entityName>CHAMPIONS BIOTECHNOLOGY, INC.</entityName>
        <issuerAddress>
            <street1>Science and Technology Park at Johns Hop</street1>
            <street2>855 N. Wolfe Street, Suite 619</street2>
            <city>Baltimore</city>
            <stateOrCountry>MD</stateOrCountry>
            <zipCode>21205</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>410-369-0365</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>CHAMPIONS SPORTS INC</previousName>
            <previousName>INTERNATIONAL GROUP INC</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Sidransky, M.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Douglas</firstName>
                <middleName>D.</middleName>
                <lastName>Burkett, Ph.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName>R.</middleName>
                <lastName>Schonau</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>M.</middleName>
                <lastName>Martell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Abba</firstName>
                <middleName>D.</middleName>
                <lastName>Poliakoff</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ana</firstName>
                <middleName>I.</middleName>
                <lastName>Stancic</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>855 N. Wolfe Street, Suite 619</street1>
                <city>Baltimore</city>
                <stateOrCountry>MD</stateOrCountry>
                <zipCode>21205</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-12-21</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>25000</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>10000000</totalOfferingAmount>
            <totalAmountSold>2100000</totalAmountSold>
            <totalRemaining>7900000</totalRemaining>
            <clarificationOfResponse>Reflects U.S. sales only as of 12/31/09 in reliance on Regulation D.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>3</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CHAMPIONS BIOTECHNOLOGY, INC.</issuerName>
                <signatureName>/s/ Mark R. Schonau</signatureName>
                <nameOfSigner>Mark R. Schonau</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-12-31</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
