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Property and equipment (Details Textual) - USD ($)
$ in Thousands
 3 Months Ended 12 Months Ended
Dec. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Property, Plant and Equipment [Line Items]        
Depreciation, Depletion and Amortization   $ 2,773 $ 3,046 $ 3,653
Impairment of Long-Lived Assets Held-for-use $ 400      
Synodex [Member]        
Property, Plant and Equipment [Line Items]        
Impairment of Long-Lived Assets Held-for-use   5,500   5,500
Property, Plant and Equipment [Member]        
Property, Plant and Equipment [Line Items]        
Depreciation, Depletion and Amortization   $ 1,900 $ 2,500 $ 3,000