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v3.3.1.900

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Income Statement [Abstract] |  |  |
Product revenue | $ 6,452 | $ 352 | $ 2,300
Royalty revenue | 1,165 | 40 | 41
Contract revenue | 1,571 | 1,402 | 602
Development revenue | 0 | 1,691 | 2,909
Total revenue | 9,188 | 3,485 | 5,852
Cost of product revenue | 6,384 | 228 | 1,518
Cost of contract revenue | 796 | 816 | 283
Total cost of revenue | 7,180 | 1,044 | 1,801
Gross profit | 2,008 | 2,441 | 4,051
Research and development expense | 8,680 | 9,067 | 10,544
Sales, marketing, general and administrative expense | 7,879 | 7,005 | 8,757
Gain on sale of previously reserved inventory | (1) | (463) | (156)
Total operating expenses | 16,558 | 15,609 | 19,145
Loss from operations | (14,550) | (13,168) | (15,094)
Gain (loss) on warrant exchange | 0 | (4,967) | 1,900
Other income, net | 8 | 15 | 16
Net loss | $ (14,542) | $ (18,120) | $ (13,178)
Net loss per share - basic and diluted | $ (0.31) | $ (0.44) | $ (0.47)
Weighted-average shares outstanding - basic and diluted | 46,540 | 41,599 | 28,025

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