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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Income Statement [Abstract]      
Product revenue $ 6,452 $ 352 $ 2,300
Royalty revenue 1,165 40 41
Contract revenue 1,571 1,402 602
Development revenue 0 1,691 2,909
Total revenue 9,188 3,485 5,852
Cost of product revenue 6,384 228 1,518
Cost of contract revenue 796 816 283
Total cost of revenue 7,180 1,044 1,801
Gross profit 2,008 2,441 4,051
Research and development expense 8,680 9,067 10,544
Sales, marketing, general and administrative expense 7,879 7,005 8,757
Gain on sale of previously reserved inventory (1) (463) (156)
Total operating expenses 16,558 15,609 19,145
Loss from operations (14,550) (13,168) (15,094)
Gain (loss) on warrant exchange 0 (4,967) 1,900
Other income, net 8 15 16
Net loss $ (14,542) $ (18,120) $ (13,178)
Net loss per share - basic and diluted $ (0.31) $ (0.44) $ (0.47)
Weighted-average shares outstanding - basic and diluted 46,540 41,599 28,025