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v3.8.0.1

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Statement [Abstract] |  |  |
Product revenue | $ 2,300 | $ 12,849 | $ 6,452
Royalty revenue | 1,568 | 1,803 | 1,165
Contract revenue | 7,023 | 109 | 1,571
Total revenue | 10,891 | 14,761 | 9,188
Cost of product revenue | 4,359 | 10,320 | 6,384
Cost of contract revenue | 5,517 | 54 | 796
Total cost of revenue | 9,876 | 10,374 | 7,180
Gross profit | 1,015 | 4,387 | 2,008
Research and development expense | 15,096 | 12,134 | 8,680
Sales, marketing, general and administrative expense | 10,156 | 8,743 | 7,879
Gain on sale of previously reserved inventory | 0 | (32) | (1)
Total operating expenses | 25,252 | 20,845 | 16,558
Loss from operations | (24,237) | (16,458) | (14,550)
Other income (expense), net | (6) | (14) | 8
Net loss | $ (24,243) | $ (16,472) | $ (14,542)
Net loss per share - basic and diluted | $ (0.33) | $ (0.32) | $ (0.31)
Weighted-average shares outstanding - basic and diluted | 72,786 | 51,958 | 46,540

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