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Segment Information (Tables) | 9 Months Ended
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Sep. 30, 2025
Segment Reporting [Abstract] |
Schedule of Reconciliation of Significant Segment Expenses | A reconciliation of the Company’s significant segment expenses to net loss is as follows:
|  | Three Months Ended September 30, |  |  | Nine Months Ended September 30, |
(in thousands) |  | 2025 |  |  | 2024 |  |  | 2025 |  |  | 2024 |
External R&D program expenses: |  |  |  |  |  |  |  |  |  |  |  |
ARTISTRY-6 |  | $ | (4,802 | ) |  | $ | 3,075 |  |  | $ | 3,898 |  |  | $ | 6,907 |
ARTISTRY-7 |  |  | (71 | ) |  |  | 4,801 |  |  |  | 4,778 |  |  |  | 15,591 |
Early discovery programs |  |  | 11 |  |  |  | 700 |  |  |  | 5,341 |  |  |  | 2,142 |
Other external R&D program expenses(1) |  |  | 77 |  |  |  | 8,737 |  |  |  | 16,217 |  |  |  | 25,198 |
Total external R&D program expenses |  |  | (4,785 | ) |  |  | 17,313 |  |  |  | 30,234 |  |  |  | 49,838 |
Internal R&D expenses: |  |  |  |  |  |  |  |  |  |  |  |
Employee-related |  |  | 493 |  |  |  | 7,635 |  |  |  | 12,386 |  |  |  | 24,143 |
Other internal R&D expenses(2) |  |  | 4 |  |  |  | 2,637 |  |  |  | 3,794 |  |  |  | 8,016 |
Total internal R&D expenses |  |  | 497 |  |  |  | 10,272 |  |  |  | 16,180 |  |  |  | 32,159 |
Total R&D expenses |  |  | (4,288 | ) |  |  | 27,585 |  |  |  | 46,414 |  |  |  | 81,997 |
G&A expenses: |  |  |  |  |  |  |  |  |  |  |  |
Employee-related |  |  | 980 |  |  |  | 3,443 |  |  |  | 6,823 |  |  |  | 11,170 |
Other G&A expenses(3) |  |  | 7,274 |  |  |  | 3,070 |  |  |  | 16,469 |  |  |  | 9,241 |
Total G&A expenses |  |  | 8,254 |  |  |  | 6,513 |  |  |  | 23,292 |  |  |  | 20,411 |
Restructuring expenses: |  |  |  |  |  |  |  |  |  |  |  |
Employee-related |  |  | — |  |  |  | — |  |  |  | 9,457 |  |  |  | — |
Other restructuring expenses(4) |  |  | — |  |  |  | — |  |  |  | 8,029 |  |  |  | — |
Total restructuring expenses: |  |  | — |  |  |  | — |  |  |  | 17,486 |  |  |  | — |
Other segment (income) expense(5) |  |  | (260 | ) |  |  | (2,339 | ) |  |  | (2,367 | ) |  |  | (8,168 | )
Segment net loss |  | $ | 3,706 |  |  | $ | 31,759 |  |  | $ | 84,825 |  |  | $ | 94,240 |
(1) Other external R&D program expenses included in segment net loss include expenses related to other clinical trials and general external program expenses. (2) Other internal R&D expenses included in segment net loss include expenses related to occupancy and depreciation. (3) Other G&A expenses included in segment net loss include expenses related to professional fees, information technology, depreciation, and other general G&A expenses. (4) Other restructuring expenses include contract termination costs, impairment and asset write-offs incurred in connection with our reduction-in-force and the termination of certain development programs. (5) Other non-operating (income) expense included in segment net loss includes interest income, tax expense, and other non-operating income and expense.

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- Definition Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 25 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-25 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-22 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 30 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482810/280-10-50-30 + Details
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