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Condensed Consolidated Statements of Cash Flows
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2025
USD ($)
Sep. 30, 2025
USD ($)
Sep. 30, 2024
USD ($)
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net loss   $ (84,825) $ (94,240)
Adjustments to reconcile net loss to cash flows from operating activities:      
Depreciation $ 800 2,788 2,644
Impairment on lab equipment held-for-sale 200 3,246 0
Write-off of prepaid expenses related to program terminations   2,549 0
Share-based compensation expense   (499) 4,419
Amortization of discount on marketable securities   (97) (2,961)
Changes in assets and liabilities:      
Receivable from Former Parent   51 4,155
Prepaid expenses   3,915 (5,999)
Other current assets   891 36
Right-of-use assets   3,649 4,114
Other assets   10 (27)
Accounts payable and accrued expenses   (13,800) (3,591)
Operating lease liabilities   (4,475) (5,463)
Other liabilities   (45) 138
Cash flows used in operating activities   (86,642) (96,775)
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchases of marketable securities   0 (167,475)
Sales and maturities of marketable securities   29,000 106,000
Proceeds from sale of property and equipment   780 0
Additions of property and equipment   (15) (69)
Cash flows provided by (used in) investing activities   29,765 (61,544)
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from issuance of ordinary shares under employee share plans   28 196
Cash flows provided by financing activities   28 196
Net decrease in cash, cash equivalents and restricted cash   (56,849) (158,123)
Cash, cash equivalents and restricted cash-beginning of period   117,431 271,110
Cash, cash equivalents and restricted cash-end of period 60,582 60,582 112,987
RECONCILIATION OF BALANCE SHEET TO STATEMENT OF CASH FLOWS:      
Cash and cash equivalents 58,871 58,871 111,018
Restricted cash, current 1,711 1,711 0
Restricted cash, noncurrent 0 0 1,969
Total cash, cash equivalents and restricted cash as shown in the statement of cash flows $ 60,582 $ 60,582 $ 112,987