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Off balance sheet commitments - Additional Information (Details)
€ in Millions, $ in Millions
3 Months Ended 9 Months Ended 12 Months Ended
Dec. 19, 2022
USD ($)
Nov. 08, 2022
USD ($)
Oct. 04, 2022
USD ($)
Sep. 27, 2022
USD ($)
Aug. 17, 2022
USD ($)
Jul. 05, 2022
USD ($)
Mar. 29, 2022
USD ($)
Mar. 15, 2022
EUR (€)
Mar. 02, 2022
USD ($)
Jan. 11, 2022
USD ($)
Jan. 07, 2022
USD ($)
molecule
Feb. 27, 2017
EUR (€)
Mar. 31, 2022
Dec. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2016
target
Dec. 31, 2022
EUR (€)
Mar. 29, 2022
EUR (€)
target
Dec. 31, 2021
EUR (€)
Apr. 08, 2021
USD ($)
Dec. 31, 2020
EUR (€)
Feb. 28, 2014
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to research and development relating to projects in research phase | €                                 € 18,000   € 6,700      
Commitments related to research and development payments contingent upon attainment of sales targets | €                                 18,500   8,100      
Commitments related to collaboration, discovery, development and commercialization agreements | €                                 8,800   5,800      
Commitments related to attainment of regulatory and sales milestones for commercialized products | €                                 7,600   4,200      
Cumulative development costs incurred | €                                     8,400      
Total credit facilities | €                                 8,000   8,000   € 8,000  
Commitments received in respect of disposals proceeds receivable and contingent consideration on divestments                           $ 1,000.0 $ 1,000.0              
Sanofi Belgium                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to collaboration, discovery, development and commercialization agreements | €                                 1,000   1,000      
Kymab                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to collaboration, discovery, development and commercialization agreements | €                                 200   500      
Commitments related to milestone payments for projects under collaboration agreements                                       $ 350.0    
World Health Organization                                            
Provisions and other non-current liabilities [Line Items]                                            
Percentage of pandemic vaccines agreed to transfer                                           7.50%
Percentage of pandemic vaccines agreed to reserve                                           7.50%
Joint ventures                                            
Provisions and other non-current liabilities [Line Items]                                            
Percentage of future development expense funded by other party                       5000.00%                    
Dice Molecules                                            
Provisions and other non-current liabilities [Line Items]                                            
Targets that encompass all diseases areas | target                               12            
Lonza | Joint ventures                                            
Provisions and other non-current liabilities [Line Items]                                            
Investments in joint ventures | €                       € 300                    
Percentage of future development expense funded by company                       50.00%                    
Amounts payable partners in collaboration agreements | €                       € 600                    
Share of operating expenses and cost of production to joint partner payable period                       15 years                    
ABL Bio                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment                   $ 75.0                        
ABL Bio | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to milestone payments for projects under collaboration agreements                   $ 985.0                        
Adagene, Inc                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment                 $ 17.5                          
Adagene, Inc | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to milestone payments for projects under collaboration agreements                 $ 2,500.0                          
Blackstone Life Sciences | Antibodies collaboration agreement                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments related to maximum payments for projects under collaboration agreement | €               € 300                            
IGM Biosciences, Inc                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment             $ 150.0                              
IGM Biosciences, Inc | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Number of oncology targets under collaboration agreement | target                                   3        
Number of immunology or inflammation targets under collaboration agreement | target                                   3        
Contingent consideration collaboration agreements | €                                   € 6,000        
Skyhawk Therapeutics, Inc                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment           $ 54.0                                
Skyhawk Therapeutics, Inc | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements           $ 2,000.0                                
miRecule                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment     $ 20.0                                      
miRecule | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements     $ 400.0                                      
Innate Pharma SA                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment $ 25.0                                          
Innate Pharma SA | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements $ 1,400.0                                          
Exscientia                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment                     $ 100.0                      
Exscientia | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Number of novel small molecule candidates developed | molecule                     15                      
Commitments related to milestone payments for projects under collaboration agreements                     $ 5,200.0                      
Atomwise                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment         $ 20.0                                  
Atomwise | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements         $ 1,000.0                                  
Scribe Therapeutics                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment       $ 25.0                                    
Scribe Therapeutics | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements       $ 1,000.0                                    
Insilico Medicine                                            
Provisions and other non-current liabilities [Line Items]                                            
Upfront payment   $ 12.5                                        
Insilico Medicine | Maximum                                            
Provisions and other non-current liabilities [Line Items]                                            
Contingent consideration collaboration agreements   $ 1,200.0                                        
Regeneron Pharmaceuticals, INC | Antibodies collaboration agreement                                            
Provisions and other non-current liabilities [Line Items]                                            
Commitments received for development costs | €                                 € 2,700   € 2,900      
Maximum additional profit-share, in percentage of Regeneron's quarterly profit (in percent)                         10.00% 20.00%                
Percentage of cumulative development costs reimbursed                             50.00%