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Principal alliances - Alliance Arrangements with Bristol-Myers Squibb (Details)
$ in Millions
 1 Months Ended 12 Months Ended
Feb. 28, 2020
USD ($)
Dec. 31, 2018
USD ($)
Dec. 31, 2022
product
Entities and companies managed by Bristol Mayers Squibb      
Disclosure of Principal Alliances [Line Items]      
Percentage of voting equity interests acquired 50.10%    
Purchase of interests in investments accounted for using equity method $ 12    
Bristol-Myers Squibb      
Disclosure of Principal Alliances [Line Items]      
Number of leading products jointly developed | product     2
Royalty payment to be paid by Sanofi   $ 200