<SEC-DOCUMENT>0001840706-24-000024.txt : 20240403
<SEC-HEADER>0001840706-24-000024.hdr.sgml : 20240403
<ACCEPTANCE-DATETIME>20240403154226
ACCESSION NUMBER:		0001840706-24-000024
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20240403
DATE AS OF CHANGE:		20240403

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOPHiA GENETICS SA
		CENTRAL INDEX KEY:			0001840706
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-40627
		FILM NUMBER:		24818484

	BUSINESS ADDRESS:	
		STREET 1:		LA PIECE, CH-1180
		CITY:			ROLLE
		STATE:			V8
		ZIP:			00000
		BUSINESS PHONE:		41 21 694 10 60

	MAIL ADDRESS:	
		STREET 1:		LA PIECE, CH-1180
		CITY:			ROLLE
		STATE:			V8
		ZIP:			00000

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Xu Zhenyu
		CENTRAL INDEX KEY:			0002006362
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		SOPHIA GENETICS SA
		STREET 2:		LA PIECE 12
		CITY:			ROLLE
		STATE:			V6
		ZIP:			1180
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0002006362</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001840706</issuerCik>
      <issuerName>SOPHiA GENETICS SA</issuerName>
      <secFileNumber>001-40627</secFileNumber>
      <issuerAddress>
        <com:street1>La Piece 12 CH-1180</com:street1>
        <com:street2>Rolle</com:street2>
        <com:city>Switzerland</com:city>
        <com:stateOrCountry>XX</com:stateOrCountry>
        <com:zipCode>00000</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>41216941060</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Zhenyu Xu</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>13640</noOfUnitsSold>
      <aggregateMarketValue>67654.4</aggregateMarketValue>
      <noOfUnitsOutstanding>65230559</noOfUnitsOutstanding>
      <approxSaleDate>04/03/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <acquiredDate>04/03/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of Restricted Stock Units Grant</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>SOPHiA GENETICS SA</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>13640</amountOfSecuritiesAcquired>
      <paymentDate>04/03/2024</paymentDate>
      <natureOfPayment>Vesting of Restricted Stock Unit Grant</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>01/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>441.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>01/22/2024</saleDate>
      <amountOfSecuritiesSold>16</amountOfSecuritiesSold>
      <grossProceeds>76</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>438.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>02/22/2024</saleDate>
      <amountOfSecuritiesSold>16</amountOfSecuritiesSold>
      <grossProceeds>76.8</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/14/2024</saleDate>
      <amountOfSecuritiesSold>8000</amountOfSecuritiesSold>
      <grossProceeds>36240</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/18/2024</saleDate>
      <amountOfSecuritiesSold>93</amountOfSecuritiesSold>
      <grossProceeds>414.78</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
        <address>
          <com:street1>1 New York Plaza</com:street1>
          <com:street2>8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>ORDINARY</securitiesClassTitle>
      <saleDate>03/22/2024</saleDate>
      <amountOfSecuritiesSold>111</amountOfSecuritiesSold>
      <grossProceeds>527.25</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The Reporting Person is selling the securities set forth herein pursuant to an automatic "sell to cover" transaction that did not represent a discretionary trade by the Reporting Person in order to pay the tax liability arising from the vesting and settlement of restricted stock units.</remarks>
    <noticeSignature>
      <noticeDate>04/03/2024</noticeDate>
      <signature>/s/ Zhenyu Xu</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
