<SEC-DOCUMENT>0001840706-26-000269.txt : 20260805
<SEC-HEADER>0001840706-26-000269.hdr.sgml : 20260805
<ACCEPTANCE-DATETIME>20260805161357
ACCESSION NUMBER:		0001840706-26-000269
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20260804
FILED AS OF DATE:		20260805
DATE AS OF CHANGE:		20260805

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Xu Zhenyu
		CENTRAL INDEX KEY:			0002006362
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-40627
		FILM NUMBER:		261243685

	MAIL ADDRESS:	
		STREET 1:		SOPHIA GENETICS SA
		STREET 2:		LA PIECE 12
		CITY:			ROLLE
		STATE:			V6
		ZIP:			1180

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SOPHiA GENETICS SA
		CENTRAL INDEX KEY:			0001840706
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMPUTER PROCESSING & DATA PREPARATION [7374]
		ORGANIZATION NAME:           	06 Technology
		EIN:				000000000
		STATE OF INCORPORATION:			V8
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		LA PIECE, CH-1180
		CITY:			ROLLE
		STATE:			V8
		ZIP:			00000
		BUSINESS PHONE:		41 21 694 10 60

	MAIL ADDRESS:	
		STREET 1:		LA PIECE, CH-1180
		CITY:			ROLLE
		STATE:			V8
		ZIP:			00000
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wk-form4_1785960834.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0609</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-08-04</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001840706</issuerCik>
        <issuerName>SOPHiA GENETICS SA</issuerName>
        <issuerTradingSymbol>SOPH</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002006362</rptOwnerCik>
            <rptOwnerName>Xu Zhenyu</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>true</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>C/O SOPHIA GENETICS SA</rptOwnerStreet1>
            <rptOwnerStreet2>LA PIECE 12</rptOwnerStreet2>
            <rptOwnerCity>ROLLE</rptOwnerCity>
            <rptOwnerNonUSStateTerritory></rptOwnerNonUSStateTerritory>
            <rptOwnerCountry>V8</rptOwnerCountry>
            <rptOwnerZipCode>1180</rptOwnerZipCode>
            <rptOwnerStateDescription>SWITZERLAND</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Scientific Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>1</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Ordinary Shares</value>
            </securityTitle>
            <transactionDate>
                <value>2026-08-04</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>6.9168</value>
                    <footnoteId id="F2"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>600887</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).</footnote>
        <footnote id="F2">The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.90 to $6.95, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Elimara Brunetto as Attorney-in-fact for Zhenyu Xu</signatureName>
        <signatureDate>2026-08-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
