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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating Loss Carryforwards [Line Items]        
Effective tax rate (0.50%) (0.90%) (2.70%)  
Tax expense attributable to the change in valuation allowance $ 39,200      
Favorable excess tax benefits for equity compensation and research credits 8,600      
Federal NOL carryforwards subject to expiration 16,900      
Capitalized research and development costs 29,991 $ 0    
Operating loss carryforwards, state, tax effected 14,800 14,100    
Net change in total valuation allowance 38,200      
Valuation allowance 132,581 94,399    
Unrecognized tax benefits 4,488 3,089 $ 2,277 $ 1,575
Unrecognized tax benefits that would affect effective tax rate if recognized 0 0    
Switzerland | Tax Year 2015        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards (8,100)      
Domestic Tax Authority        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 237,700 239,900    
Federal NOL carryforwards not subject to expiration 220,800      
Federal tax credit carryforwards 19,300 13,700    
State and Local Jurisdiction        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 256,300 249,800    
Foreign Tax Authority | Switzerland        
Operating Loss Carryforwards [Line Items]        
Operating loss carryforwards 163,400 $ 126,600    
Valuation allowance 18,700      
Foreign Tax Authority | Germany        
Operating Loss Carryforwards [Line Items]        
Valuation allowance $ (1,100)