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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating Loss Carryforwards [Line Items] |  |  |  |
Effective tax rate (percent) | (1.20%) | (3.00%) | (0.50%) |
Tax expense attributable to the change in valuation allowance | $ 27,600 | $ 27,300 | $ 39,200 |
Favorable tax benefits for research credits | 6,700 | 10,300 | 8,600 |
Federal NOL carryforwards subject to expiration | 16,600 |  |  |
Capitalized research and development costs | 45,820 | 35,047 |  |
Operating loss carryforwards, state, tax effected | 17,800 | 17,000 |  |
Valuation allowance | 187,969 | 161,966 |  |
Unrecognized tax benefits | 7,840 | 6,484 | $ 4,488 | $ 3,089
Unrecognized tax benefits that would affect effective tax rate if recognized | 0 | 0 |  |
Domestic Tax Jurisdiction |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |
Operating loss carryforwards | 287,500 | 295,900 |  |
Federal NOL carryforwards not subject to expiration | 270,900 |  |  |
Federal tax credit carryforwards | 32,500 | 27,200 |  |
State and Local Jurisdiction |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |
Operating loss carryforwards | 297,500 | 306,800 |  |
Foreign Tax Jurisdiction |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |
Operating loss carryforwards | 29,000 | 21,800 |  |
Foreign Tax Jurisdiction | Switzerland |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |
Operating loss carryforwards | 230,100 | $ 192,300 |  |
Valuation allowance | 26,200 |  |  |
Foreign Tax Jurisdiction | Switzerland | Tax Year 2016 |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |
Expired operating loss carryforwards | $ 1,000 |  |  |

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