<?xml version="1.0" encoding="utf-8"?>
<xs:schema xmlns:flutterentertainment="http://flutterentertainment.com/xbrl/2022" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" targetNamespace="http://flutterentertainment.com/xbrl/2022" xmlns:xs="http://www.w3.org/2001/XMLSchema">
  <xs:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance" />
  <xs:import schemaLocation="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor.xsd" namespace="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor" />
  <xs:import schemaLocation="http://www.xbrl.org/lrr/arcrole/esma-arcrole-2018-11-21.xsd" namespace="http://www.esma.europa.eu/xbrl/esef/arcrole/wider-narrower" />
  <xs:import schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" namespace="http://www.xbrl.org/dtr/type/non-numeric" />
  <xs:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt" />
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="635400EG4YIJLJMZJ782-2022-12-31_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="635400EG4YIJLJMZJ782-2022-12-31_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="635400EG4YIJLJMZJ782-2022-12-31_lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="635400EG4YIJLJMZJ782-2022-12-31_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-lab-en.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple" />
      <link:linkbaseRef xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="http://www.esma.europa.eu/taxonomy/2021-03-24/esef_cor-gen-en.xml" xlink:type="simple" />
      <link:roleType id="Anchoring" roleURI="http://flutterentertainment.com/xbrl/2022/roles/Anchoring">
        <link:definition>99 - Groups all anchored elements</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ProfitOrLoss" roleURI="http://flutterentertainment.com/xbrl/2022/roles/ProfitOrLoss">
        <link:definition>01 - Profit or loss</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfComprehensiveIncome" roleURI="http://flutterentertainment.com/xbrl/2022/roles/StatementOfComprehensiveIncome">
        <link:definition>02 - Statement of comprehensive income</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfComprehensiveIncomeParenthetical" roleURI="http://flutterentertainment.com/xbrl/2022/roles/StatementOfComprehensiveIncomeParenthetical">
        <link:definition>03 - Statement of comprehensive income (Parenthetical)</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfFinancialPosition" roleURI="http://flutterentertainment.com/xbrl/2022/roles/StatementOfFinancialPosition">
        <link:definition>04 - Statement of financial position</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfCashFlows" roleURI="http://flutterentertainment.com/xbrl/2022/roles/StatementOfCashFlows">
        <link:definition>05 - Statement of cash flows</link:definition>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StatementOfChangesInEquity" roleURI="http://flutterentertainment.com/xbrl/2022/roles/StatementOfChangesInEquity">
        <link:definition>06 - Statement of changes in equity</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
      <link:roleType id="NotesAndMandatoryItems" roleURI="http://flutterentertainment.com/xbrl/2022/roles/NotesAndMandatoryItems">
        <link:definition>07 - Notes and Mandatory Items</link:definition>
        <link:usedOn>link:definitionLink</link:usedOn>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:labelLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
  <xs:element id="flutterentertainment_OperatingCostsExcludingDepreciationAmortisationAndGainOnDisposal" xbrli:balance="debit" xbrli:periodType="duration" name="OperatingCostsExcludingDepreciationAmortisationAndGainOnDisposal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_EBITDA" xbrli:balance="credit" xbrli:periodType="duration" name="EBITDA" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_AmortisationOfAcquisitionRelatedIntangibleAssets" xbrli:balance="debit" xbrli:periodType="duration" name="AmortisationOfAcquisitionRelatedIntangibleAssets" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_ForeignExchangeLossOnNetInvestmentHedgesNetOfTax" xbrli:balance="credit" xbrli:periodType="duration" name="ForeignExchangeLossOnNetInvestmentHedgesNetOfTax" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_ForeignExchangeGainLossOnTranslationOfTheNetAssetsOfForeignCurrencyDenominatedEntities" xbrli:balance="credit" xbrli:periodType="duration" name="ForeignExchangeGainLossOnTranslationOfTheNetAssetsOfForeignCurrencyDenominatedEntities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_IncomeTaxIncludedInForeignExchangeGainLossOnNetInvestmentHedges" xbrli:balance="credit" xbrli:periodType="duration" name="IncomeTaxIncludedInForeignExchangeGainLossOnNetInvestmentHedges" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_IssuedShareCapitalAndSharePremium" xbrli:balance="credit" xbrli:periodType="instant" name="IssuedShareCapitalAndSharePremium" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_SeperatelyDisclosedItemsIncludedWithinEBITDA" xbrli:balance="debit" xbrli:periodType="duration" name="SeperatelyDisclosedItemsIncludedWithinEBITDA" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_AdjustmentsForIncreaseInTradeOtherPayablesAndProvisions" xbrli:balance="debit" xbrli:periodType="duration" name="AdjustmentsForIncreaseInTradeOtherPayablesAndProvisions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_MovementInCashAndCashEquivalentsCustomerBalances" xbrli:balance="debit" xbrli:periodType="duration" name="MovementInCashAndCashEquivalentsCustomerBalances" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_CashGeneratedFromOperationsNetOfTaxesPaid" xbrli:balance="debit" xbrli:periodType="duration" name="CashGeneratedFromOperationsNetOfTaxesPaid" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_TransactionFeesRestructuringAndIntegrationCostsPaidClassifiedAsOperatingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="TransactionFeesRestructuringAndIntegrationCostsPaidClassifiedAsOperatingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_AmountsPaidInRespectOfKentuckyLitigationClassifiedAsOperatingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="AmountsPaidInRespectOfKentuckyLitigationClassifiedAsOperatingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_ProceedsFromTheIssueOfSharesOnExerciseOfEmployeeOptionsClassifiedAsFinancingActivities" xbrli:balance="debit" xbrli:periodType="duration" name="ProceedsFromTheIssueOfSharesOnExerciseOfEmployeeOptionsClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_ProceedsFromTheIssuanceOfNewSharesInRespectOfEquityPlacementClassifiedAsFinancingActivities" xbrli:balance="debit" xbrli:periodType="duration" name="ProceedsFromTheIssuanceOfNewSharesInRespectOfEquityPlacementClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_PaymentOfLeaseInterestClassifiedAsFinancingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="PaymentOfLeaseInterestClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_LeaseIncentiveReceivedClassifiedAsFinancingActivities" xbrli:balance="debit" xbrli:periodType="duration" name="LeaseIncentiveReceivedClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_SettlementOfDerivativesClassifiedAsFinancingActivities" xbrli:balance="credit" xbrli:periodType="duration" name="SettlementOfDerivativesClassifiedAsFinancingActivities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_IssuedShareCapitalAndSharePremiumMember" xbrli:periodType="duration" abstract="true" name="IssuedShareCapitalAndSharePremiumMember" nillable="true" substitutionGroup="xbrli:item" type="nonnum:domainItemType" />
  <xs:element id="flutterentertainment_SharesIssuedOnExerciseOfEmployeeShareOptions" xbrli:balance="credit" xbrli:periodType="duration" name="SharesIssuedOnExerciseOfEmployeeShareOptions" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_LiabilityRecognisedOnPutOption" xbrli:balance="debit" xbrli:periodType="duration" name="LiabilityRecognisedOnPutOption" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_ChangesInEquityRelatingToBusinessCombinations" xbrli:balance="credit" xbrli:periodType="duration" name="ChangesInEquityRelatingToBusinessCombinations" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_OrdinarySharesOfTheCompanyAcquiredByTheEmployeeBenefitTrust" xbrli:balance="debit" xbrli:periodType="duration" name="OrdinarySharesOfTheCompanyAcquiredByTheEmployeeBenefitTrust" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_EquitysettledTransactionsExpenseRecordedInTheIncomeStatement" xbrli:balance="credit" xbrli:periodType="duration" name="EquitysettledTransactionsExpenseRecordedInTheIncomeStatement" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_EquitySettledTransactionsVesting" xbrli:balance="credit" xbrli:periodType="duration" name="EquitySettledTransactionsVesting" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_TransferToRetainedEarningsOnExerciseOf" xbrli:balance="debit" xbrli:periodType="duration" name="TransferToRetainedEarningsOnExerciseOf" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_MergerReserveCapitalisation" xbrli:balance="credit" xbrli:periodType="duration" name="MergerReserveCapitalisation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" />
  <xs:element id="flutterentertainment_DisclosureOfIBORReform" xbrli:periodType="duration" name="DisclosureOfIBORReform" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DescriptionOfAccountingPolicyForCostOfSales" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForCostOfSales" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DescriptionOfAccountingPolicyForBankAndCreditCardCharges" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForBankAndCreditCardCharges" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DescriptionOfAccountingPolicyForSeparatelyDisclosedItems" xbrli:periodType="duration" name="DescriptionOfAccountingPolicyForSeparatelyDisclosedItems" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfSeparatelyDisclosedItems" xbrli:periodType="duration" name="DisclosureOfSeparatelyDisclosedItems" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfStatutoryAndOtherInformation" xbrli:periodType="duration" name="DisclosureOfStatutoryAndOtherInformation" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfInvestmentsAndTradeAndOtherReceivables" xbrli:periodType="duration" name="DisclosureOfInvestmentsAndTradeAndOtherReceivables" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfCurrentInvestmentsFinancialAssetsRestrictedCashAndCashEquivalents" xbrli:periodType="duration" name="DisclosureOfCurrentInvestmentsFinancialAssetsRestrictedCashAndCashEquivalents" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfForeignCurrencyRisk" xbrli:periodType="duration" name="DisclosureOfForeignCurrencyRisk" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
  <xs:element id="flutterentertainment_DisclosureOfInterestRateRisk" xbrli:periodType="duration" name="DisclosureOfInterestRateRisk" nillable="true" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType" />
</xs:schema>