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Segment Reporting - Reconciliation of Segment Profits to Income Before Taxes (Details) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Segment Reporting Information [Line Items]    
Profits $ 2,003 $ 1,624
Interest income 97 79
Interest expense (182) (172)
Equity income from affiliates (13) 34
Depreciation and amortization (1,193) (1,561)
Research and development (1,796) (1,659)
Restructuring costs (151) (91)
Total segment profits    
Segment Reporting Information [Line Items]    
Profits 5,632 5,472
Total segment profits | Pharmaceutical segment    
Segment Reporting Information [Line Items]    
Profits 5,180 5,117
Total segment profits | Other segments    
Segment Reporting Information [Line Items]    
Profits 452 355
Other profits    
Segment Reporting Information [Line Items]    
Profits 142 227
Unallocated    
Segment Reporting Information [Line Items]    
Interest income 97 79
Interest expense (182) (172)
Equity income from affiliates (12) 20
Depreciation and amortization (370) (428)
Research and development (1,599) (1,373)
Amortization of purchase accounting adjustments (778) (1,133)
Restructuring costs (151) (91)
Other unallocated, net $ (776) $ (977)