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Acquisitions, Divestitures, Research Collaborations and License Agreements - Collaborative Arrangements Narrative (Details) - USD ($)
$ in Millions
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Research and development     $ 1,749 $ 2,151 $ 3,545 $ 3,810
Subsequent event | AstraZeneca            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Upfront and milestone payments made to collaborative partner $ 1,600          
Payments to acquire intangible assets 750          
Maximum amount of contingent payments collaborative arrangement 6,150          
Total consideration from collaborative arrangement (up to value) $ 8,500          
Period of notice for agreement termination 180 days          
Forecast | AstraZeneca            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Research and development   $ 2,350