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Segment Reporting - Reconciliation of Segment Profits to Income Before Taxes (Details) - USD ($) $ in Millions | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2017 | Sep. 30, 2016
Segment Reporting Information [Line Items] |  |  |  |
Profits | $ 200 | $ 2,887 | $ 4,642 | $ 6,015
Interest income | 90 | 87 | 284 | 244
Interest expense | (189) | (170) | (564) | (513)
Equity income from affiliates | 18 | 21 | 11 | 59
Depreciation and amortization |  |  | (3,509) | (4,286)
Research and development | (4,383) | (1,664) | (7,927) | (5,475)
Restructuring costs | (153) | (161) | (470) | (386)
Total segment profits |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Profits | 6,411 | 6,551 | 18,164 | 17,827
Total segment profits | Pharmaceutical segment |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Profits | 5,929 | 6,162 | 16,722 | 16,698
Total segment profits | Other segments |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Profits | 482 | 389 | 1,442 | 1,129
Other profits |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Profits | (78) | 21 | 107 | 341
Unallocated |  |  |  |
Segment Reporting Information [Line Items] |  |  |  |
Interest income | 90 | 87 | 284 | 244
Interest expense | (189) | (170) | (564) | (513)
Equity income from affiliates | 23 | (27) | 16 | (13)
Depreciation and amortization | (334) | (365) | (1,036) | (1,228)
Research and development | (1,829) | (1,444) | (4,955) | (4,651)
Aggregate charge related to the formation of an oncology collaboration with AstraZeneca | (2,350) | 0 | (2,350) | 0
Amortization of purchase accounting adjustments | (765) | (772) | (2,322) | (2,933)
Restructuring costs | (153) | (161) | (470) | (386)
Gain on sale of certain migraine clinical development programs | 0 | 40 | 0 | 40
Other unallocated, net | $ (626) | $ (873) | $ (2,232) | $ (2,713)

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