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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2017 | Sep. 30, 2016
Cash Flows from Operating Activities |  |
Net income | $ 3,456 | $ 4,528
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Depreciation and amortization | 3,509 | 4,286
Intangible asset impairment charges | 376 | 572
Charge for future payments related to AstraZeneca collaboration license options | 750 | 0
Deferred income taxes | (601) | (65)
Share-based compensation | 232 | 225
Other | (31) | 200
Net changes in assets and liabilities | (5,259) | (3,002)
Net Cash Provided by Operating Activities | 2,432 | 6,744
Cash Flows from Investing Activities |  |
Capital expenditures | (1,173) | (1,063)
Purchases of securities and other investments | (8,397) | (10,084)
Proceeds from sales of securities and other investments | 12,533 | 11,300
Acquisitions of businesses, net of cash acquired | (347) | (778)
Other | 121 | (22)
Net Cash Provided by (Used in) Investing Activities | 2,737 | (647)
Cash Flows from Financing Activities |  |
Net change in short-term borrowings | 1,962 | 909
Payments on debt | (301) | (2,386)
Purchases of treasury stock | (2,312) | (2,418)
Dividends paid to stockholders | (3,884) | (3,853)
Proceeds from exercise of stock options | 481 | 790
Other | (167) | (109)
Net Cash Used in Financing Activities | (4,221) | (7,067)
Effect of Exchange Rate Changes on Cash and Cash Equivalents | 438 | 353
Net Increase (Decrease) in Cash and Cash Equivalents | 1,386 | (617)
Cash and Cash Equivalents at Beginning of Year | 6,515 | 8,524
Cash and Cash Equivalents at End of Period | $ 7,901 | $ 7,907

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section 45 -Paragraph 1 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3044-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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