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Taxes on Income - Narrative (Details) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
Income Tax Examination [Line Items]        
Effective income tax rate 125.50% 24.20% 25.50% 24.70%
Research and development $ 4,383 $ 1,664 $ 7,927 $ 5,475
Tax benefit related to settlement of state income tax issue     $ (88)  
Internal Revenue Service (IRS)        
Income Tax Examination [Line Items]        
Net tax benefit related to settlement of federal income tax issues 234      
Tax payment related to settlement of federal income examination 2,800      
AstraZeneca        
Income Tax Examination [Line Items]        
Charge related to collaboration formation $ 2,350