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Acquisitions, Divestitures, Research Collaborations and License Agreements - Divestitures Narrative (Detail) - USD ($)
1 Months Ended 12 Months Ended
Apr. 30, 2016
Aug. 31, 2015
Feb. 28, 2015
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Jul. 31, 2015
Acquisitions Divestitures Research Collaborations and License Agreements Transactions [Line Items]              
Agreement term     2 years        
Proceeds from sale of intangible assets       $ 85,000,000 $ 170,000,000    
ophthalmic products              
Acquisitions Divestitures Research Collaborations and License Agreements Transactions [Line Items]              
Proceeds from divestiture of business           $ 170,000,000  
Gain on disposition of business           147,000,000  
CGRP receptor antagonists              
Acquisitions Divestitures Research Collaborations and License Agreements Transactions [Line Items]              
Total Consideration Received For Sale Of Asset             $ 250,000,000
Proceeds from collaborators $ 125,000,000 $ 125,000,000          
Gain (loss) on sale of clinical development programs         $ 100,000,000 $ 250,000,000