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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Cash Flows from Operating Activities    
Net income $ 741 $ 1,556
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization 1,137 1,193
Intangible asset impairment charges 0 80
Charge for future payments related to Eisai collaboration license options 650 0
Deferred income taxes (30) (54)
Share-based compensation 80 74
Other 50 (28)
Net changes in assets and liabilities (1,473) (2,535)
Net Cash Provided by Operating Activities 1,155 286
Cash Flows from Investing Activities    
Capital expenditures (450) (339)
Purchases of securities and other investments (1,326) (2,929)
Proceeds from sales of securities and other investments 1,848 6,819
Acquisitions of businesses, net of cash acquired 0 (306)
Other (269) (52)
Net Cash (Used in) Provided by Investing Activities (197) 3,193
Cash Flows from Financing Activities    
Net change in short-term borrowings (1) 3,784
Payments on debt (1,003) (300)
Purchases of treasury stock (566) (1,019)
Dividends paid to stockholders (1,299) (1,294)
Proceeds from exercise of stock options 230 313
Other (83) (23)
Net Cash (Used in) Provided by Financing Activities (2,722) 1,461
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash 154 253
Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash (1,610) 5,193
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $4 million at January 1, 2018 included in Other Assets) 6,096 6,515
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $4 million at January 1, 2018 included in Other Assets) $ 4,486 $ 11,708