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Segment Reporting - Reconciliation of Segment Profits to Income Before Taxes (Details) - USD ($)
$ in Millions
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Segment Reporting Information [Line Items]    
Profits $ 1,345 $ 2,003
Interest income 85 97
Interest expense (185) (182)
Equity income from affiliates (52) (13)
Depreciation and amortization (1,137) (1,193)
Research and development (3,196) (1,830)
Restructuring costs (95) (151)
Total segment profits    
Segment Reporting Information [Line Items]    
Profits 6,280 5,610
Total segment profits | Pharmaceutical segment    
Segment Reporting Information [Line Items]    
Profits 5,804 5,160
Total segment profits | Animal Health segment    
Segment Reporting Information [Line Items]    
Profits 413 417
Total segment profits | Other segments    
Segment Reporting Information [Line Items]    
Profits 63 33
Other profits    
Segment Reporting Information [Line Items]    
Profits (87) 142
Unallocated    
Segment Reporting Information [Line Items]    
Interest income 85 97
Interest expense (185) (182)
Equity income from affiliates (50) (12)
Depreciation and amortization (350) (370)
Research and development (2,982) (1,632)
Amortization of purchase accounting adjustments (733) (778)
Restructuring costs (95) (151)
Other unallocated, net $ (538) $ (721)