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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Millions | 6 Months Ended
--- | ---
Jun. 30, 2018 | Jun. 30, 2017
Cash Flows from Operating Activities |  |
Net income | $ 2,457 | $ 3,507
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Depreciation and amortization | 2,363 | 2,355
Intangible asset impairment charges | 0 | 131
Charge for future payments related to Eisai collaboration license options | 650 | 0
Deferred income taxes | (258) | (272)
Share-based compensation | 170 | 156
Other | 429 | 63
Net changes in assets and liabilities | (1,274) | (2,337)
Net Cash Provided by Operating Activities | 4,537 | 3,603
Cash Flows from Investing Activities |  |
Capital expenditures | (1,033) | (732)
Purchases of securities and other investments | (5,248) | (6,280)
Proceeds from sales of securities and other investments | 7,403 | 9,363
Other acquisitions, net of cash acquired | (372) | (347)
Other | (274) | 62
Net Cash Provided by Investing Activities | 476 | 2,066
Cash Flows from Financing Activities |  |
Net change in short-term borrowings | 2,069 | (24)
Payments on debt | (3,008) | (301)
Purchases of treasury stock | (2,162) | (2,153)
Dividends paid to stockholders | (2,610) | (2,601)
Proceeds from exercise of stock options | 299 | 408
Other | (277) | (86)
Net Cash Used in Financing Activities | (5,689) | (4,757)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | (108) | 359
Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash | (784) | 1,271
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $4 million at January 1, 2018 included in Other Assets) | 6,096 | 6,515
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $4 million at January 1, 2018 included in Other Assets) | $ 5,312 | $ 7,786

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