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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Millions | 9 Months Ended
--- | ---
Sep. 30, 2018 | Sep. 30, 2017
Cash Flows from Operating Activities |  |
Net income | $ 4,415 | $ 3,456
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Depreciation and amortization | 3,424 | 3,509
Intangible asset impairment charges | 0 | 376
Charge for future payments related to collaboration license options | 650 | 750
Charge for collaboration termination | 420 | 0
Deferred income taxes | (391) | (601)
Share-based compensation | 261 | 232
Other | 585 | (31)
Net changes in assets and liabilities | (2,034) | (5,259)
Net Cash Provided by Operating Activities | 7,330 | 2,432
Cash Flows from Investing Activities |  |
Capital expenditures | (1,686) | (1,173)
Purchases of securities and other investments | (6,899) | (8,397)
Proceeds from sales of securities and other investments | 11,243 | 12,533
Acquisitions, net of cash acquired | (372) | (347)
Other | (150) | 121
Net Cash Provided by Investing Activities | 2,136 | 2,737
Cash Flows from Financing Activities |  |
Net change in short-term borrowings | 2,294 | 1,962
Payments on debt | (3,007) | (301)
Purchases of treasury stock | (3,158) | (2,312)
Dividends paid to stockholders | (3,895) | (3,884)
Proceeds from exercise of stock options | 461 | 481
Other | (289) | (167)
Net Cash Used in Financing Activities | (7,594) | (4,221)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | (140) | 438
Net Increase in Cash, Cash Equivalents and Restricted Cash | 1,732 | 1,386
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $4 million at January 1, 2018 included in Other Assets) | 6,096 | 6,515
Cash, Cash Equivalents and Restricted Cash at End of Period (includes restricted cash of $2 million at September 30, 2018 included in Other Assets) | $ 7,828 | $ 7,901

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