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Collaborative Arrangements - Narrative (Details) $ in Millions | 1 Months Ended | 12 Months Ended | 35 Months Ended
--- | --- | --- | ---
Mar. 31, 2019 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jul. 31, 2017 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($) | Dec. 31, 2018 USD ($) payment | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Jan. 31, 2021 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  | $ 9,752 | $ 10,339 | $ 10,261 |
Noncurrent liabilities |  |  | $ 11,117 |  |  |  |  | 12,041 | 11,117 |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  | 2,900 | 3,200 | 3,800 |
Estimated aggregate amortization expense, 2019 |  |  |  |  |  |  |  | 1,500 |  |  |
Estimated aggregate amortization expense, 2020 |  |  |  |  |  |  |  | 1,200 |  |  |
Estimated aggregate amortization expense, 2021 |  |  |  |  |  |  |  | 1,100 |  |  |
Estimated aggregate amortization expense, 2022 |  |  |  |  |  |  |  | 1,100 |  |  |
Estimated aggregate amortization expense, 2023 |  |  |  |  |  |  |  | 1,100 |  |  |
Capitalized Licenses |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  | 186 | 39 | $ 30 |
Estimated aggregate amortization expense, 2019 |  |  |  |  |  |  |  | 196 |  |  |
Estimated aggregate amortization expense, 2020 |  |  |  |  |  |  |  | 193 |  |  |
Estimated aggregate amortization expense, 2021 |  |  |  |  |  |  |  | 191 |  |  |
Estimated aggregate amortization expense, 2022 |  |  |  |  |  |  |  | 187 |  |  |
Estimated aggregate amortization expense, 2023 |  |  |  |  |  |  |  | 181 |  |  |
Lynparza | Other Assets |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Intangible assets |  |  |  |  |  |  |  | 743 |  |  |
Lenvima | Other Assets |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Intangible assets |  |  |  |  |  |  |  | 479 |  |  |
Adempas | Other Intangible Assets, Net |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Intangible assets |  |  |  |  |  |  |  | 1,000 |  |  |
AstraZeneca |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  |  |  | $ 1,600 |  |  |  |  |  |  |
Payments to acquire intangible assets |  |  | $ 250 | $ 750 |  |  |  | 400 |  |  |
Research and development |  |  |  |  |  |  |  |  | $ 2,350 |  |
AstraZeneca | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  | 3,400 |  |  |
AstraZeneca | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  | 1,760 |  |  |
AstraZeneca | Lynparza |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  | $ 58 |  |  |
AstraZeneca | Lynparza | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of milestone payments | payment |  |  |  |  |  |  |  | 3 |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  | $ 600 |  |  |
Liabilities |  |  |  |  |  |  |  | 600 |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  | 150 |  |  |
AstraZeneca | Lynparza | Prior Year Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  | 100 |  |  |
AstraZeneca | Lynparza | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  | 140 |  |  |
AstraZeneca | Forecast |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payments to acquire intangible assets |  |  |  |  |  |  | $ 100 |  |  |  |
Eisai |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  | $ 750 |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  | 1,400 |  |  |
Eisai | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  | 3,970 |  |  |  |  |  | 3,710 |  |  |
Eisai | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  | $ 385 |  |  |  |  |  | $ 135 |  |  |
Eisai | Lenvima | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of milestone payments | payment |  |  |  |  |  |  |  | 3 |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  | $ 268 |  |  |
Liabilities |  |  |  |  |  |  |  | 268 |  |  |
Intangible assets |  |  |  |  |  |  |  | 268 |  |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  | 24 |  |  |
Eisai | Lenvima | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  | 250 |  |  |
Eisai | Forecast |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Payments to acquire intangible assets | $ 325 |  |  |  | $ 125 | $ 200 |  |  |  |  | $ 650
Bayer AG | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  | 400 |  |  |
Bayer AG | Adempas |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  | 106 |  |  |
Bayer AG | Adempas | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  | 375 |  |  |
Noncurrent liabilities |  |  |  |  |  |  |  | 375 |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  | $ 350 |  |  |

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