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Goodwill and Other Intangibles - Narrative (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | $ 11,431 | $ 14,183 |
Intangible asset impairment charge related to marketed product |  | 58 | $ 347
IPR&D impairment charges | 152 | 483 | 3,600
Changes in estimated fair value | 89 | 141 |
Amortization expense for intangible assets | 2,900 | 3,200 | 3,800
Estimated aggregate amortization expense, 2019 | 1,500 |  |
Estimated aggregate amortization expense, 2020 | 1,200 |  |
Estimated aggregate amortization expense, 2021 | 1,100 |  |
Estimated aggregate amortization expense, 2022 | 1,100 |  |
Estimated aggregate amortization expense, 2023 | 1,100 |  |
Zerbaxa |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 2,700 |  |
Sivextro |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 833 |  |
Implanon/Nexplanon |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 470 |  |
Dificid |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 395 |  |
Gardasil/Gardasil 9 |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 384 |  | 468
Bridion |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 275 |  |
Simponi |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 194 |  |
Adempas |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net | 1,000 |  |
Intron A |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Intangible asset impairment charge related to marketed product |  | 47 |
Zontivity |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Intangible asset impairment charge related to marketed product |  |  | 252
Grastek/Ragwitek |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Intangible asset impairment charge related to marketed product |  |  | 95
SmartCells Program |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges | 139 |  | 72
Changes in estimated fair value | $ (60) |  |
uprifosbuvir |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
Other intangibles, net |  |  | 240
IPR&D impairment charges |  | 240 | 2,900
verubecestat |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges |  | $ 226 |
monoclonal antibody (cCAM) |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges |  |  | 180
BET inhibitor (OncoEthix) |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges |  |  | 143
House Dust Mite |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges |  |  | 112
Next Generation Ring |  |  |
Intangible Assets Excluding Goodwill [Line Items] |  |  |
IPR&D impairment charges |  |  | $ 79

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