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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Millions | 3 Months Ended
--- | ---
Mar. 31, 2019 | Mar. 31, 2018
Cash Flows from Operating Activities |  |
Net income | $ 2,862 | $ 741
Adjustments to reconcile net income to net cash provided by operating activities: |  |
Depreciation and amortization | 898 | 1,137
Intangible asset impairment charges | 104 | 0
Charge for future payments related to collaboration license options | 0 | 650
Deferred income taxes | 194 | (30)
Share-based compensation | 93 | 80
Other | 120 | 50
Net changes in assets and liabilities | (2,935) | (1,473)
Net Cash Provided by Operating Activities | 1,336 | 1,155
Cash Flows from Investing Activities |  |
Capital expenditures | (595) | (450)
Purchases of securities and other investments | (974) | (1,326)
Proceeds from sales of securities and other investments | 1,899 | 1,848
Other | 38 | (269)
Net Cash Provided by (Used in) Investing Activities | 368 | (197)
Cash Flows from Financing Activities |  |
Net change in short-term borrowings | (4,135) | (1)
Payments on debt | 0 | (1,003)
Proceeds from issuance of debt | 4,958 | 0
Purchases of treasury stock | (1,090) | (566)
Dividends paid to stockholders | (1,428) | (1,299)
Proceeds from exercise of stock options | 173 | 230
Other | (92) | (83)
Net Cash Used in Financing Activities | (1,614) | (2,722)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | 20 | 154
Net Increase (Decrease) in Cash, Cash Equivalents and Restricted Cash | 110 | (1,610)
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $2 million at January 1, 2019 included in Other Assets) | 7,967 | 6,096
Cash, Cash Equivalents and Restricted Cash at End of Period (includes restricted cash of $1 million at March 31, 2019 included in Other Assets) | $ 8,077 | $ 4,486

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