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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($)
$ in Millions
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Cash Flows from Operating Activities    
Net income $ 2,862 $ 741
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization 898 1,137
Intangible asset impairment charges 104 0
Charge for future payments related to collaboration license options 0 650
Deferred income taxes 194 (30)
Share-based compensation 93 80
Other 120 50
Net changes in assets and liabilities (2,935) (1,473)
Net Cash Provided by Operating Activities 1,336 1,155
Cash Flows from Investing Activities    
Capital expenditures (595) (450)
Purchases of securities and other investments (974) (1,326)
Proceeds from sales of securities and other investments 1,899 1,848
Other 38 (269)
Net Cash Provided by (Used in) Investing Activities 368 (197)
Cash Flows from Financing Activities    
Net change in short-term borrowings (4,135) (1)
Payments on debt 0 (1,003)
Proceeds from issuance of debt 4,958 0
Purchases of treasury stock (1,090) (566)
Dividends paid to stockholders (1,428) (1,299)
Proceeds from exercise of stock options 173 230
Other (92) (83)
Net Cash Used in Financing Activities (1,614) (2,722)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash 20 154
Net Increase (Decrease) in Cash, Cash Equivalents and Restricted Cash 110 (1,610)
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $2 million at January 1, 2019 included in Other Assets) 7,967 6,096
Cash, Cash Equivalents and Restricted Cash at End of Period (includes restricted cash of $1 million at March 31, 2019 included in Other Assets) $ 8,077 $ 4,486