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Collaborative Arrangements - Narrative (Details) - USD ($) $ in Millions | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended | 18 Months Ended | 37 Months Ended
--- | --- | --- | --- | --- | --- | ---
Mar. 31, 2021 | Mar. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2019 | Apr. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Jul. 31, 2017 | Jun. 30, 2019 | Mar. 31, 2019 | Jun. 30, 2018 | Mar. 31, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2018 | Mar. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  |  |  |  | $ 2,189 |  | $ 2,274 |  | $ 4,119 | $ 5,470 |  |  |  |
Other liabilities, noncurrent |  |  |  | $ 11,283 |  |  | $ 12,041 |  |  |  | 11,283 |  |  |  | 11,283 |  | $ 12,041 |  | $ 12,041 |
Lynparza | Other Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets |  |  |  | 1,000 |  |  |  |  |  |  | 1,000 |  |  |  | 1,000 |  |  |  |  |
Lenvima | Other Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets |  |  |  | 687 |  |  |  |  |  |  | 687 |  |  |  | 687 |  |  |  |  |
Adempas | Other intangible assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Finite-lived intangible assets |  |  |  | 956 |  |  |  |  |  |  | 956 |  |  |  | 956 |  |  |  |  |
AstraZeneca |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,600 |  |
License option payment related to collaborative arrangement |  |  |  |  |  |  | $ 400 |  | $ 250 | $ 750 |  |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 2,350 |  |
AstraZeneca | Forecast |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License option payment related to collaborative arrangement |  |  | $ 100 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
AstraZeneca | Lynparza |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative amortization expense |  |  |  |  |  |  |  |  |  |  | 52 |  |  |  |  |  |  |  |  |
AstraZeneca | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Probable contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 700 |
Contingent milestone payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,100 |  |  |  |  |
AstraZeneca | Sales-Based Milestones | Lynparza |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Probable contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  | 300 |  |  |  |  |  |  |  |  |
Liabilities |  |  |  | 300 |  |  |  |  |  |  | $ 300 |  |  |  | 300 |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 250 |  |  |
AstraZeneca | Regulatory Milestones | Lynparza |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  | $ 30 | $ 30 |  |  |  |  |  |  |  |  |  |  |  | 140 |  |  |
Contingent milestone payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,700 |  |  |  |  |
Eisai |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  |  |  |  |  |  |  | $ 750 |  |  |  |  |  |  |  |  |  |  |  |
License option payment related to collaborative arrangement |  |  |  |  |  | $ 325 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,400 |  | 1,400 |  |  |  |
Eisai | Forecast |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License option payment related to collaborative arrangement | $ 125 | $ 200 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 650
Eisai | Lenvima |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative amortization expense |  |  |  |  |  |  |  |  |  |  |  | $ 35 |  |  |  |  |  |  |  |
Eisai | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent milestone payments collaborative arrangement |  |  |  |  |  |  |  | 3,970 |  |  |  |  |  |  | 3,420 |  |  |  |  |
Eisai | Sales-Based Milestones | Lenvima |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Probable contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  | 282 |  |  |  |  | 268 |  |  |
Liabilities |  |  |  |  |  | $ 282 |  |  |  |  |  | $ 282 |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50 |  |  |  |  |
Eisai | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent milestone payments collaborative arrangement |  |  |  |  |  |  |  | $ 385 |  |  |  |  |  |  | 135 |  |  |  |  |
Eisai | Regulatory Milestones | Lenvima |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 250 |  |  |
Bayer AG | Adempas |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cumulative amortization expense |  |  |  |  |  |  |  |  |  |  |  |  | 106 |  |  |  |  |  |  |
Bayer AG | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Probable contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  | 375 |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 350 |  |  |  |  |  |
Contingent milestone payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 400 |  |  |  |  |
Other liabilities, noncurrent |  |  |  |  |  |  |  |  |  |  |  |  | $ 375 |  |  | $ 375 |  |  |  |

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