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Consolidated Statement of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash Flows from Operating Activities |  |  |
Net income | $ 7,082 | $ 9,777 | $ 6,193
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Amortization | 1,899 | 1,973 | 3,103
Depreciation | 1,726 | 1,679 | 1,416
Intangible asset impairment charges | 1,718 | 1,040 | 296
Charge for the acquisition of VelosBio Inc. | 2,660 | 0 | 0
Charge for the acquisition of Peloton Therapeutics, Inc. | 0 | 993 | 0
Charge for future payments related to collaboration license options | 0 | 0 | 650
Deferred income taxes | (668) | (556) | (509)
Share-based compensation | 475 | 417 | 348
Other | (49) | 184 | 978
Net changes in assets and liabilities: |  |  |
Accounts receivable | (1,002) | 294 | (418)
Inventories | (855) | (508) | (911)
Trade accounts payable | 724 | 399 | 230
Accrued and other current liabilities | (1,138) | 376 | (341)
Income taxes payable | 560 | (2,359) | 827
Noncurrent liabilities | (453) | (237) | (266)
Other | (2,426) | (32) | (674)
Net Cash Provided by Operating Activities | 10,253 | 13,440 | 10,922
Cash Flows from Investing Activities |  |  |
Capital expenditures | (4,684) | (3,473) | (2,615)
Purchase of Seagen Inc. common stock | (1,000) | 0 | 0
Purchases of securities and other investments | (95) | (3,202) | (7,994)
Proceeds from sales of securities and other investments | 2,812 | 8,622 | 15,252
Acquisition of VelosBio Inc., net of cash acquired | (2,696) | 0 | 0
Acquisition of ArQule, Inc., net of cash acquired | (2,545) | 0 | 0
Acquisition of Antelliq Corporation, net of cash acquired | 0 | (3,620) | 0
Acquisition of Peloton Therapeutics, Inc., net of cash acquired | 0 | (1,040) | 0
Other acquisitions, net of cash acquired | (1,365) | (294) | (431)
Other | 130 | 378 | 102
Net Cash (Used in) Provided by Investing Activities | (9,443) | (2,629) | 4,314
Cash Flows from Financing Activities |  |  |
Net change in short-term borrowings | 2,549 | (3,710) | 5,124
Payments on debt | (1,957) | 0 | (4,287)
Proceeds from issuance of debt | 4,419 | 4,958 | 0
Purchases of treasury stock | (1,281) | (4,780) | (9,091)
Dividends paid to stockholders | (6,215) | (5,695) | (5,172)
Proceeds from exercise of stock options | 89 | 361 | 591
Other | (436) | 5 | (325)
Net Cash Used in Financing Activities | (2,832) | (8,861) | (13,160)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | 253 | 17 | (205)
Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash | (1,769) | 1,967 | 1,871
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes $258 of restricted cash at January 1, 2020 included in Other Assets - see Note 6) | 9,934 | 7,967 | 6,096
Cash, Cash Equivalents and Restricted Cash at End of Year (includes $103 of restricted cash at December 31, 2020 included in Other Assets - see Note 6) | $ 8,165 | $ 9,934 | $ 7,967

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