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Collaborative Arrangements - Narrative (Details) - USD ($) $ in Millions | 1 Months Ended | 12 Months Ended | 35 Months Ended
--- | --- | --- | ---
Mar. 31, 2021 | Jan. 31, 2021 | Mar. 31, 2020 | Dec. 31, 2019 | Mar. 31, 2019 | Dec. 31, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | Jul. 31, 2017 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018 | Jan. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  |  |  | $ 13,558 | $ 9,872 | $ 9,752 |
Noncurrent liabilities |  |  |  | $ 11,970 |  |  |  |  |  | 12,482 | 11,970 |  |
Amortization expense for intangible assets |  |  |  |  |  |  |  |  |  | 1,900 | 2,000 | 3,100 |
Other intangibles, net |  |  |  | 14,196 |  |  |  |  |  | 14,604 | 14,196 |  |
Estimated aggregate amortization expense, 2021 |  |  |  |  |  |  |  |  |  | 1,500 |  |  |
Estimated aggregate amortization expense, 2022 |  |  |  |  |  |  |  |  |  | 1,500 |  |  |
Estimated aggregate amortization expense, 2023 |  |  |  |  |  |  |  |  |  | 1,400 |  |  |
Estimated aggregate amortization expense, 2024 |  |  |  |  |  |  |  |  |  | 1,300 |  |  |
Estimated aggregate amortization expense, 2025 |  |  |  |  |  |  |  |  |  | 1,200 |  |  |
Licenses |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other intangibles, net |  |  |  | 2,361 |  |  |  |  |  | 2,790 | 2,361 |  |
Lynparza | Licenses |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other intangibles, net |  |  |  |  |  |  |  |  |  | 1,300 |  |  |
Lenvima | Licenses |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Other intangibles, net |  |  |  |  |  |  |  |  |  | 1,100 |  |  |
Adempas | Other Intangible Assets, Net |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Intangible assets |  |  |  |  |  |  |  |  |  | 849 |  |  |
AstraZeneca |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  |  |  |  |  |  |  |  | $ 1,600 |  |  |  |
Payments to acquire intangible assets |  |  |  | $ 100 |  | $ 400 |  | $ 250 | $ 750 |  |  |  |
AstraZeneca | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 2,700 |  |  |
AstraZeneca | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 1,400 |  |  |
AstraZeneca | Lynparza | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 400 | 1,000 |  |
Liabilities |  |  |  |  |  |  |  |  |  | 400 |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  | 550 | 200 | 250 |
AstraZeneca | Lynparza | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  | 160 | 60 | 140 |
Eisai |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront and milestone payments |  |  |  |  |  |  | $ 750 |  |  |  |  |  |
Payments to acquire intangible assets |  |  | $ 200 |  | $ 325 |  |  |  |  |  |  |  |
Research and development |  |  |  |  |  |  |  |  |  |  |  | 1,400 |
Eisai | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 2,600 |  |  |
Eisai | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 125 |  |  |
Eisai | Lenvima | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  | 400 | 950 |  |
Liabilities |  |  |  |  |  |  |  |  |  | 400 |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  | 500 | 50 |  |
Eisai | Lenvima | Regulatory Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  | 10 |  | 250 |
Eisai | Forecast |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Payments to acquire intangible assets | $ 125 |  |  |  |  |  |  |  |  |  |  |  | $ 650
Bayer AG | Adempas | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Probable future contingent payments collaborative arrangement |  |  |  |  |  |  |  |  |  |  | $ 725 |  |
Milestone payments made to collaborative partner |  |  |  |  |  |  |  |  |  | $ 375 |  | $ 350 |
Subsequent Event | Bayer AG | Sales-Based Milestones |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |
Probable future contingent payments collaborative arrangement |  | $ 400 |  |  |  |  |  |  |  |  |  |  |
Liabilities |  | $ 400 |  |  |  |  |  |  |  |  |  |  | $ 400

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