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Segment Reporting - Reconciliation of Segment Profits to Income Before Taxes (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Segment Reporting Information [Line Items]      
Interest income $ 59 $ 274 $ 343
Interest expense (831) (893) (772)
Research and development (13,558) (9,872) (9,752)
Restructuring costs (578) (638) (632)
Income Before Taxes 8,791 11,464 8,701
Total segment profits      
Segment Reporting Information [Line Items]      
Depreciation and amortization (855) (653) (503)
Income Before Taxes 31,373 29,926 26,633
Total segment profits | Pharmaceutical segment      
Segment Reporting Information [Line Items]      
Depreciation and amortization (690) (534) (411)
Income Before Taxes 29,722 28,324 24,871
Total segment profits | Animal Health      
Segment Reporting Information [Line Items]      
Depreciation and amortization (164) (109) (82)
Income Before Taxes 1,650 1,609 1,659
Total segment profits | Other segments      
Segment Reporting Information [Line Items]      
Depreciation and amortization (1) (10) (10)
Income Before Taxes 1 (7) 103
Other profits      
Segment Reporting Information [Line Items]      
Income Before Taxes 140 363 6
Unallocated      
Segment Reporting Information [Line Items]      
Interest income 59 274 343
Interest expense (831) (893) (772)
Depreciation and amortization (1,602) (1,593) (1,352)
Research and development (13,072) (9,499) (9,432)
Amortization of purchase accounting adjustments (1,168) (1,406) (2,664)
Restructuring costs (578) (638) (632)
Charge related to the termination of a collaboration with Samsung 0 0 (423)
Other unallocated, net $ (5,530) $ (5,070) $ (3,006)