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Goodwill and Other Intangibles - Narrative (Details) - USD ($)
$ in Millions
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net $ 14,604 $ 14,196  
Intangible asset impairment charge related to marketed product   705  
IPR&D impairment charges   172 $ 152
Changes in estimated fair value 83 64  
Amortization expense for intangible assets 1,900 2,000 3,100
Estimated aggregate amortization expense, 2021 1,500    
Estimated aggregate amortization expense, 2022 1,500    
Estimated aggregate amortization expense, 2023 1,400    
Estimated aggregate amortization expense, 2024 1,300    
Estimated aggregate amortization expense, 2025 1,200    
Zerbaxa      
Intangible Assets Excluding Goodwill [Line Items]      
Intangible asset impairment charge related to marketed product 1,600    
Inventory Write-down 120    
Sivextro      
Intangible Assets Excluding Goodwill [Line Items]      
Intangible asset impairment charge related to marketed product   612  
Animal Health      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 5,400    
Adempas | Other      
Intangible Assets Excluding Goodwill [Line Items]      
Intangible assets 849    
IOmet Pharma Ltd      
Intangible Assets Excluding Goodwill [Line Items]      
IPR&D impairment charges   155  
Changes in estimated fair value   (11)  
SmartCells Program      
Intangible Assets Excluding Goodwill [Line Items]      
IPR&D impairment charges     139
Changes in estimated fair value     $ (60)
COVID-19      
Intangible Assets Excluding Goodwill [Line Items]      
IPR&D impairment charges 90    
Changes in estimated fair value (45)    
Products and product rights      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 5,162 7,095  
Products and product rights | Zerbaxa      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 551    
Products and product rights | Sivextro      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 154    
Products and product rights | Implanon/Nexplanon      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 354    
Products and product rights | Dificid      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 228    
Products and product rights | Gardasil/Gardasil 9      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 276    
Products and product rights | Bridion      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 185    
Products and product rights | Simponi      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 132    
Trade names      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 2,530 2,682  
Licenses      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 2,790 $ 2,361  
Licenses | Lenvima      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 1,100    
Licenses | Lynparza      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net 1,300    
Antelliq | Trade names      
Intangible Assets Excluding Goodwill [Line Items]      
Other intangibles, net $ 2,500