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Acquisitions, Research Collaborations and License Agreements - Acquisitions (Details) - USD ($)
$ in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Jan. 16, 2020
Apr. 30, 2021
Jan. 31, 2021
Dec. 31, 2020
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Contingent consideration       $ 841.0 $ 816.0 $ 694.0 $ 841.0 $ 767.0
Goodwill       20,238.0 20,212.0   20,238.0  
Research and development         2,465.0 2,209.0    
Inventories       6,310.0 6,402.0   6,310.0  
Payments to Acquire Productive Assets         1,134.0 $ 986.0    
COVID-19                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Charges related to program discontinuation         $ 170.0      
ArQule                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Payment to acquire business $ 2,700.0              
IPR&D 2,280.0              
Share-based compensation payments attributable to precombination service 138.0              
Transaction costs 95.0              
Cash and cash equivalents 145.0              
Goodwill 512.0              
Other assets and liabilities, net 34.0              
Deferred income tax liabilities 361.0              
Intangible assets $ 80.0              
OncoImmune                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Payment to acquire business       423.0        
Other assets and liabilities, net       (22.0)     $ (22.0)  
Payments to Acquire Investments       $ 50.0        
Equity Method Investment, Ownership Percentage       20.00%     20.00%  
Investments       $ 33.0     $ 33.0  
Premium on shares acquired       $ 17.0        
Research and Development Asset Acquired Other than Through Business Combination, Written-off             $ 462.0  
Pandion Therapeutics | Subsequent Event                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Payment to acquire business   $ 1,850.0            
Gilead Sciences | oral and injectable formulations programs | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
proft share         40.00%      
profit share counterparty         60.00%      
Gilead Sciences | oral formulation | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
proft share         35.00%      
profit share counterparty         65.00%      
Sales threshold         $ 2,000.0      
Gilead Sciences | injectable formulation | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
proft share         35.00%      
profit share counterparty         65.00%      
Sales threshold         $ 3,500.0      
Artiva Biotherapeutics, Inc. | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Upfront and milestone payments     $ 30.0          
Upfront and milestone payments to be made     $ 15.0          
Artiva Biotherapeutics, Inc. | Minimum | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Royalty Rate, Percentage     7.00%          
Artiva Biotherapeutics, Inc. | Maximum | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Royalty Rate, Percentage     14.00%          
Artiva Biotherapeutics, Inc. | Development Milestones | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Contingent milestone payments collaborative arrangement     $ 217.5          
Artiva Biotherapeutics, Inc. | Sales-Based Milestones | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Contingent milestone payments collaborative arrangement     1,050.0          
Artiva Biotherapeutics, Inc. | Regulatory Milestones | Licensing Agreements                
Acquisitions Research Collaborations And License Agreements Transactions [Line Items]                
Contingent milestone payments collaborative arrangement     $ 570.0