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Collaborative Arrangements - Narrative (Details) course in Thousands, $ in Millions | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 USD ($) course | Nov. 30, 2021 course | Mar. 31, 2021 USD ($) | Dec. 31, 2021 USD ($) course market country | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other intangibles, net | $ 22,933 |  |  | $ 22,933 | $ 14,101 |
Amortization |  |  |  | $ 1,636 | 1,817 | $ 1,695
Number of markets (more than) | market |  |  |  | 30 |  |
Number of low and middle income countries (more than) | country |  |  |  | 100 |  |
Supply Commitment to United States |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Quantity committed (in courses) | course | 3,100 |  |  |  |  |
Quantity delivered (in courses) | course |  |  |  | 888 |  |
Supply Commitment to Japan |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Quantity committed (in courses) | course | 1,600 |  |  |  |  |
Quantity delivered (in courses) | course |  |  |  | 200 |  |
Supply Commitment to United Kingdom |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Quantity committed (in courses) | course |  | 2,230 |  |  |  |
Quantity delivered (in courses) | course |  |  |  | 152 |  |
Supply Commitment to United Nations Children's Fund |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Quantity committed (in courses) | course |  |  |  | 3,000 |  |
License |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other intangibles, net | $ 3,368 |  |  | $ 3,368 | 3,553 |
Lenvima | License |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other intangibles, net | 1,000 |  |  | 1,000 |  |
Adempas | Licenses and other |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Intangible assets | 806 |  |  | 806 |  |
Verquvo |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Amortization |  |  |  | 153 |  |
Verquvo | Licenses and other |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Intangible assets | 68 |  |  | 68 |  |
Lynparza | License |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Other intangibles, net | 1,100 |  |  | 1,100 |  |
Eisai |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
License option payment related to collaborative arrangement |  |  | $ 125 |  |  |
Eisai | Lenvima | Sales-Based Milestones |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  | 200 | 500 | 50
Eisai | Lenvima | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments accrued | 600 |  |  | 600 |  |
Accrued regulatory approval milestone payment | 25 |  |  | 25 |  |
Potential Future Milestone Payments Sales-Based | 2,600 |  |  | 2,600 |  |
Potential Future Milestone Payments Regulatory | 25 |  |  | 25 |  |
Eisai | Lenvima | Regulatory Milestones |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  | 75 | 10 |
Bayer AG | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments accrued | 400 |  |  | 400 |  |
Liabilities | 400 |  |  | 400 |  |
Bayer AG | Adempas | Sales-Based Milestones |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  | 375 |
AstraZeneca | Lynparza | Sales-Based Milestones |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  | 550 | 200
AstraZeneca | Lynparza | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments accrued | 400 |  |  | 400 |  |
Potential Future Milestone Payments Sales-Based | 2,700 |  |  | 2,700 |  |
Potential Future Milestone Payments Regulatory | $ 1,400 |  |  | $ 1,400 |  |
AstraZeneca | Lynparza | Regulatory Milestones |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Milestone payments made to collaborative partner |  |  |  |  | $ 160 | $ 60

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