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Taxes on Income - Reconciliation Between Effective Tax Rate and US Statutory Rate (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Amount |  |  |
U.S. statutory rate applied to income from continuing operations before taxes | $ 2,915 | $ 1,231 | $ 1,506
Differential arising from: |  |  |
Foreign earnings | (1,446) | (965) | (461)
GILTI and the foreign-derived intangible income deduction | (75) | 349 | 323
Tax settlements | (275) | (13) | (139)
R&D tax credit | (81) | (108) | (116)
Acquisition of VelosBio | (9) | 559 | 0
Acquisition of Pandion | 356 | 0 | 0
Valuation allowances | 102 | 37 | 115
Restructuring | 61 | 105 | 39
Acquisition-related costs, including amortization | 8 | 38 | 70
State taxes | 2 | 57 | (12)
Acquisition of OncoImmune | 0 | 97 | 0
Acquisition of Peloton | 0 | 0 | 209
Tax Cuts and Jobs Act of 2017 | 0 | 0 | 117
Other | (37) | (47) | (86)
Taxes on income | $ 1,521 | $ 1,340 | $ 1,565
Tax Rate |  |  |
U.S. statutory rate applied to income from continuing operations before taxes | 21.00% | 21.00% | 21.00%
Differential arising from: |  |  |
Foreign earnings | (10.40%) | (16.50%) | (6.40%)
GILTI and the foreign-derived intangible income deduction | (0.50%) | 6.00% | 4.50%
Tax settlements | (2.00%) | (0.20%) | (1.90%)
R&D tax credit | (0.60%) | (1.80%) | (1.60%)
Acquisition of VelosBio | (0.10%) | 9.50% | 0.00%
Acquisition of Pandion | 2.60% | 0.00% | 0.00%
Valuation allowances | 0.70% | 0.60% | 1.60%
Restructuring | 0.40% | 1.80% | 0.50%
Acquisition-related costs, including amortization | 0.10% | 0.60% | 1.00%
State taxes | 0.00% | 1.00% | (0.20%)
Acquisition of OncoImmune | 0.00% | 1.70% | 0.00%
Acquisition of Peloton | 0.00% | 0.00% | 2.90%
Tax Cuts and Jobs Act of 2017 | 0 | 0 | 0.016
Other | (0.20%) | (0.80%) | (1.20%)
Total, Tax Rate | 11.00% | 22.90% | 21.80%

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