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Collaborative Arrangements - Financial Information (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Sales | $ 48,704 | $ 41,518 | $ 39,121
Cost of sales | 13,626 | 13,618 | 12,016
Selling, general and administrative | 9,634 | 8,955 | 9,455
Research and development | 12,245 | 13,397 | 9,724
Payables included in Accrued and other liabilities | 23,872 | 27,327 |
Amortization expense for intangible assets | 1,600 | 1,800 | 1,700
Other current assets | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Receivables included in Other current assets | 271 | 215 |
Other current assets | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Receivables included in Other current assets | 200 | 157 |
Other current assets | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Receivables included in Other current assets | 114 | 65 |
Accounts Payable and Accrued Liabilities | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payables included in Accrued and other liabilities | 415 | 423 |
Accounts Payable and Accrued Liabilities | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payables included in Accrued and other liabilities | 625 | 335 |
Accounts Payable and Accrued Liabilities | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payables included in Accrued and other liabilities | 472 | 0 |
Accounts Payable and Accrued Liabilities | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payables included in Accrued and other liabilities | 283 | 3 |
Other Noncurrent Liabilities | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Payables included in Other Noncurrent Liabilities | 0 | 600 |
Total sales | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Alliance revenue - profit sharing | 1,018 | 733 | 444
Total sales | AstraZeneca | Collaborative Arrangement | Alliance revenue - Lynparza |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Alliance revenue - profit sharing | 989 | 725 | 444
Total sales | AstraZeneca | Collaborative Arrangement | Alliance revenue - Koselugo |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Alliance revenue - profit sharing | 29 | 8 | 0
Total sales | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Alliance revenue - profit sharing | 704 | 580 | 404
Total sales | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Alliance revenue - profit sharing | 342 | 281 | 204
Sales | 601 | 501 | 419
Total sales | Bayer AG | Collaborative Arrangement | Adempas |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Net sales by Merck | 252 | 220 | 215
Total sales | Bayer AG | Collaborative Arrangement | Verquvo |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Net sales by Merck | 7 | 0 | 0
Total sales | Ridgeback Biotherapeutics LP | Collaborative Arrangement | Molnupiravir |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Sales | 952 | 0 |
Cost of sales | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost of sales | 167 | 247 | 148
Cost of sales | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost of sales | 195 | 271 | 206
Cost of sales | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost of sales | 424 | 196 | 188
Amortization expense for intangible assets | 153 |  |
Cost of sales | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Cost of sales | 494 | 13 |
Selling, general and administrative | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Selling, general and administrative | 178 | 160 | 138
Selling, general and administrative | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Selling, general and administrative | 127 | 73 | 80
Selling, general and administrative | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Selling, general and administrative | 126 | 47 | 34
Selling, general and administrative | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Selling, general and administrative | 33 | 6 |
Research and development | AstraZeneca | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Research and development | 120 | 133 | 168
Research and development | Eisai | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Research and development | 173 | 185 | 189
Research and development | Bayer AG | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Research and development | 53 | 63 | $ 126
Research and development | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Research and development | $ 60 | $ 323 |

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