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Consolidated Statement of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash Flows from Operating Activities of Continuing Operations |  |  |
Net income from continuing operations | $ 12,358 | $ 4,523 | $ 5,606
Adjustments to reconcile net income from continuing operations to net cash provided by operating activities of continuing operations: |  |  |
Amortization | 1,636 | 1,817 | 1,695
Depreciation | 1,578 | 1,669 | 1,615
Intangible asset impairment charges | 302 | 1,718 | 1,040
Income from investments in equity securities, net | (1,940) | (1,338) | (170)
Charge for the acquisition of Pandion Therapeutics, Inc. | 1,556 | 0 | 0
Charge for the acquisition of VelosBio Inc. | 0 | 2,660 | 0
Charge for the acquisition of Peloton Therapeutics, Inc. | 0 | 0 | 993
Deferred income taxes | 187 | (566) | (560)
Share-based compensation | 479 | 441 | 388
Other | 805 | 1,294 | 354
Net changes in assets and liabilities: |  |  |
Accounts receivable | (2,033) | (1,002) | 92
Inventories | (674) | (895) | (473)
Trade accounts payable | 405 | 684 | 443
Accrued and other current liabilities | 277 | (1,152) | 413
Income taxes payable | (540) | 814 | (1,889)
Noncurrent liabilities | 484 | (617) | (733)
Other | (1,758) | (2,433) | 70
Net Cash Provided by Operating Activities of Continuing Operations | 13,122 | 7,617 | 8,884
Cash Flows from Investing Activities of Continuing Operations |  |  |
Capital expenditures | (4,448) | (4,429) | (3,369)
Purchase of Seagen Inc. common stock | 0 | (1,000) | 0
Purchases of securities and other investments | (1) | (95) | (3,202)
Proceeds from sales of securities and other investments | 1,026 | 2,812 | 8,622
Acquisition of Acceleron Pharma Inc., net of cash acquired | (11,174) | 0 | 0
Acquisition of Pandion Therapeutics, Inc., net of cash acquired | (1,554) | 0 | 0
Acquisition of VelosBio Inc., net of cash acquired | 0 | (2,696) | 0
Acquisition of ArQule, Inc., net of cash acquired | 0 | (2,545) | 0
Acquisition of Antelliq Corporation, net of cash acquired | 0 | 0 | (3,620)
Acquisition of Peloton Therapeutics, Inc., net of cash acquired | 0 | 0 | (1,040)
Other acquisitions, net of cash acquired | (179) | (1,365) | (294)
Other | (91) | 125 | 374
Net Cash Used in Investing Activities of Continuing Operations | (16,421) | (9,193) | (2,529)
Cash Flows from Financing Activities of Continuing Operations |  |  |
Net change in short-term borrowings | (3,986) | 2,549 | (3,710)
Payments on debt | (2,319) | (1,957) | 0
Proceeds from issuance of debt | 7,936 | 4,419 | 4,958
Distribution from Organon & Co. | 9,000 | 0 | 0
Purchases of treasury stock | (840) | (1,281) | (4,780)
Dividends paid to stockholders | (6,610) | (6,215) | (5,695)
Proceeds from exercise of stock options | 202 | 89 | 361
Other | (286) | (436) | 5
Net Cash Provided by (Used in) Financing Activities of Continuing Operations | 3,097 | (2,832) | (8,861)
Discontinued Operations |  |  |
Net cash provided by operating activities | 987 | 2,636 | 4,556
Net cash used in investing activities | (134) | (250) | (100)
Net cash used in financing activities | (504) | 0 | 0
Net Cash Flows Provided by Discontinued Operations | 349 | 2,386 | 4,456
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | (133) | 253 | 17
Net Increase (Decrease) in Cash, Cash Equivalents and Restricted Cash | 14 | (1,769) | 1,967
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes $103 of restricted cash at January 1, 2021 included in Other Assets - see Note 7) | 8,153 | 9,934 | 7,967
Less: Cash and cash equivalents related to discontinued operations | 0 | 12 | 0
Cash, Cash Equivalents and Restricted Cash at End of Year (includes $71 of restricted cash at December 31, 2021 included in Other Assets - see Note 7) | $ 8,167 | $ 8,153 | $ 9,934

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- Definition The increase (decrease) during the reporting period in amount due within one year (or one business cycle) from customers for the credit sale of goods and services. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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