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Segment Reporting (Tables) | 12 Months Ended
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Dec. 31, 2021
Segment Reporting [Abstract] |
Sales of Company's Products | Sales of the Company’s products were as follows:
Years Ended December 31 | 2021 |  | 2020 |  | 2019
| U.S. |  | Int’l |  | Total |  | U.S. |  | Int’l |  | Total |  | U.S. |  | Int’l |  | Total
Pharmaceutical: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Oncology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Keytruda | $ | 9,765 |  |  | $ | 7,421 |  |  | $ | 17,186 |  |  | $ | 8,352 |  |  | $ | 6,028 |  |  | $ | 14,380 |  |  | $ | 6,305 |  |  | $ | 4,779 |  |  | $ | 11,084 |
Alliance revenue - Lynparza (1) | 515 |  |  | 473 |  |  | 989 |  |  | 417 |  |  | 308 |  |  | 725 |  |  | 269 |  |  | 176 |  |  | 444 |
Alliance revenue - Lenvima (1) | 417 |  |  | 287 |  |  | 704 |  |  | 359 |  |  | 220 |  |  | 580 |  |  | 239 |  |  | 165 |  |  | 404 |
Vaccines |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Gardasil/Gardasil 9 | 1,881 |  |  | 3,792 |  |  | 5,673 |  |  | 1,755 |  |  | 2,184 |  |  | 3,938 |  |  | 1,831 |  |  | 1,905 |  |  | 3,737 |
ProQuad/M-M-R II/Varivax | 1,629 |  |  | 506 |  |  | 2,135 |  |  | 1,378 |  |  | 500 |  |  | 1,878 |  |  | 1,683 |  |  | 592 |  |  | 2,275 |
Pneumovax 23 | 547 |  |  | 346 |  |  | 893 |  |  | 727 |  |  | 359 |  |  | 1,087 |  |  | 679 |  |  | 247 |  |  | 926 |
RotaTeq | 473 |  |  | 334 |  |  | 807 |  |  | 486 |  |  | 311 |  |  | 797 |  |  | 506 |  |  | 284 |  |  | 791 |
Vaqta | 100 |  |  | 79 |  |  | 179 |  |  | 103 |  |  | 67 |  |  | 170 |  |  | 130 |  |  | 108 |  |  | 238 |
Hospital Acute Care |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Bridion | 762 |  |  | 770 |  |  | 1,532 |  |  | 583 |  |  | 615 |  |  | 1,198 |  |  | 533 |  |  | 598 |  |  | 1,131 |
Prevymis | 153 |  |  | 218 |  |  | 370 |  |  | 119 |  |  | 162 |  |  | 281 |  |  | 84 |  |  | 81 |  |  | 165 |
Primaxin | 2 |  |  | 258 |  |  | 259 |  |  | 2 |  |  | 248 |  |  | 251 |  |  | 2 |  |  | 271 |  |  | 273 |
Noxafil | 60 |  |  | 199 |  |  | 259 |  |  | 42 |  |  | 287 |  |  | 329 |  |  | 282 |  |  | 380 |  |  | 662 |
Cancidas | 4 |  |  | 208 |  |  | 212 |  |  | 7 |  |  | 207 |  |  | 213 |  |  | 6 |  |  | 242 |  |  | 249 |
Invanz | (5) |  |  | 207 |  |  | 202 |  |  | 9 |  |  | 202 |  |  | 211 |  |  | 30 |  |  | 233 |  |  | 263 |
Zerbaxa | 4 |  |  | (5) |  |  | (1) |  |  | 74 |  |  | 56 |  |  | 130 |  |  | 63 |  |  | 58 |  |  | 121 |
Immunology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Simponi | — |  |  | 825 |  |  | 825 |  |  | — |  |  | 838 |  |  | 838 |  |  | — |  |  | 830 |  |  | 830 |
Remicade | — |  |  | 299 |  |  | 299 |  |  | — |  |  | 330 |  |  | 330 |  |  | — |  |  | 411 |  |  | 411 |
Neuroscience |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Belsomra | 78 |  |  | 241 |  |  | 318 |  |  | 81 |  |  | 247 |  |  | 327 |  |  | 92 |  |  | 214 |  |  | 306 |
Virology |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Molnupiravir | 632 |  |  | 320 |  |  | 952 |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |  |  | — |
Isentress/Isentress HD | 294 |  |  | 474 |  |  | 769 |  |  | 326 |  |  | 531 |  |  | 857 |  |  | 398 |  |  | 576 |  |  | 975 |
Cardiovascular |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Alliance revenue - Adempas/Verquvo (2) | 312 |  |  | 30 |  |  | 342 |  |  | 259 |  |  | 22 |  |  | 281 |  |  | 194 |  |  | 10 |  |  | 204 |
Adempas | — |  |  | 252 |  |  | 252 |  |  | — |  |  | 220 |  |  | 220 |  |  | — |  |  | 215 |  |  | 215 |
Diabetes |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Januvia | 1,404 |  |  | 1,920 |  |  | 3,324 |  |  | 1,470 |  |  | 1,836 |  |  | 3,306 |  |  | 1,724 |  |  | 1,758 |  |  | 3,482 |
Janumet | 367 |  |  | 1,597 |  |  | 1,964 |  |  | 477 |  |  | 1,494 |  |  | 1,971 |  |  | 589 |  |  | 1,452 |  |  | 2,041 |
Other pharmaceutical (3) | 1,007 |  |  | 1,302 |  |  | 2,310 |  |  | 984 |  |  | 1,328 |  |  | 2,312 |  |  | 1,215 |  |  | 1,661 |  |  | 2,873 |
Total Pharmaceutical segment sales | 20,401 |  |  | 22,353 |  |  | 42,754 |  |  | 18,010 |  |  | 18,600 |  |  | 36,610 |  |  | 16,854 |  |  | 17,246 |  |  | 34,100 |
Animal Health: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Livestock | 667 |  |  | 2,628 |  |  | 3,295 |  |  | 612 |  |  | 2,327 |  |  | 2,939 |  |  | 582 |  |  | 2,201 |  |  | 2,784 |
Companion Animals | 1,091 |  |  | 1,182 |  |  | 2,273 |  |  | 872 |  |  | 892 |  |  | 1,764 |  |  | 724 |  |  | 885 |  |  | 1,609 |
Total Animal Health segment sales | 1,758 |  |  | 3,810 |  |  | 5,568 |  |  | 1,484 |  |  | 3,219 |  |  | 4,703 |  |  | 1,306 |  |  | 3,086 |  |  | 4,393 |
Other segment sales (4) | — |  |  | — |  |  | — |  |  | 23 |  |  | — |  |  | 23 |  |  | 174 |  |  | 1 |  |  | 175 |
Total segment sales | 22,159 |  |  | 26,163 |  |  | 48,322 |  |  | 19,517 |  |  | 21,819 |  |  | 41,336 |  |  | 18,334 |  |  | 20,333 |  |  | 38,668 |
Other (5) | 266 |  |  | 116 |  |  | 382 |  |  | 71 |  |  | 111 |  |  | 182 |  |  | 86 |  |  | 368 |  |  | 453 |
| $ | 22,425 |  |  | $ | 26,279 |  |  | $ | 48,704 |  |  | $ | 19,588 |  |  | $ | 21,930 |  |  | $ | 41,518 |  |  | $ | 18,420 |  |  | $ | 20,701 |  |  | $ | 39,121 |
U.S. plus international may not equal total due to rounding. (1) Alliance revenue represents Merck’s share of profits, which are product sales net of cost of sales and commercialization costs (see Note 5). (2) Alliance revenue represents Merck’s share of profits from sales in Bayer’s marketing territories, which are product sales net of cost of sales and commercialization costs (see Note 5). (3) Other pharmaceutical primarily reflects sales of other human health pharmaceutical products, including products within the franchises not listed separately. (4) Represents sales for the Healthcare Services segment. All the businesses in the Healthcare Services segment were fully divested by the first quarter of 2020. (5) Other is primarily comprised of miscellaneous corporate revenues, including revenue hedging activities, as well as third-party manufacturing sales (including sales to Organon). Other for 2021 also includes $185 million related to the achievement of milestones for an out-licensed product that triggered contingent payments to Merck.
Consolidated Revenues by Geographic Area | Consolidated sales by geographic area where derived are as follows:
Years Ended December 31 | 2021 |  | 2020 |  | 2019
United States | $ | 22,425 |  |  | $ | 19,588 |  |  | $ | 18,420 |
Europe, Middle East and Africa | 13,341 |  |  | 11,547 |  |  | 10,496 |
China | 4,378 |  |  | 2,751 |  |  | 2,180 |
Japan | 2,726 |  |  | 2,602 |  |  | 2,609 |
Asia Pacific (other than China and Japan) | 2,407 |  |  | 2,113 |  |  | 2,126 |
Latin America | 2,206 |  |  | 1,890 |  |  | 2,015 |
Other | 1,221 |  |  | 1,027 |  |  | 1,275 |
| $ | 48,704 |  |  | $ | 41,518 |  |  | $ | 39,121 |
Reconciliation of Segment Profits to Income Before Taxes | A reconciliation of segment profits to Income from Continuing Operations Before Taxes is as follows:
Years Ended December 31 | 2021 |  | 2020 |  | 2019
Segment profits: |  |  |  |  |
Pharmaceutical segment | $ | 30,977 |  |  | $ | 26,106 |  |  | $ | 23,448 |
Animal Health segment | 1,950 |  |  | 1,669 |  |  | 1,612 |
Other segments | — |  |  | 1 |  |  | (7) |
Total segment profits | 32,927 |  |  | 27,776 |  |  | 25,053 |
Other profits | 156 |  |  | 75 |  |  | 295 |
Unallocated: |  |  |  |  |
Interest income | 36 |  |  | 59 |  |  | 274 |
Interest expense | (806) |  |  | (831) |  |  | (893) |
Amortization | (1,636) |  |  | (1,817) |  |  | (1,695) |
Depreciation | (1,414) |  |  | (1,519) |  |  | (1,491) |
Research and development | (11,692) |  |  | (12,911) |  |  | (9,351) |
Restructuring costs | (661) |  |  | (575) |  |  | (626) |
Other unallocated, net | (3,031) |  |  | (4,394) |  |  | (4,395) |
| $ | 13,879 |  |  | $ | 5,863 |  |  | $ | 7,171 |
Equity Loss from Affiliates and Depreciation Included in Segment Profits | Equity loss from affiliates and depreciation included in segment profits is as follows:
| Pharmaceutical |  | Animal Health |  | All Other |  | Total
Year Ended December 31, 2021 |  |  |  |  |  |  |
Included in segment profits: |  |  |  |  |  |  |
Equity loss from affiliates | $ | 11 |  |  | $ | — |  |  | $ | — |  |  | $ | 11 |
Depreciation | 6 |  |  | 158 |  |  | — |  |  | 164 |
Year Ended December 31, 2020 |  |  |  |  |  |  |
Included in segment profits: |  |  |  |  |  |  |
Equity loss from affiliates | $ | 6 |  |  | $ | — |  |  | $ | — |  |  | $ | 6 |
Depreciation | 6 |  |  | 143 |  |  | 1 |  |  | 150 |
Year Ended December 31, 2019 |  |  |  |  |  |  |
Included in segment profits: |  |  |  |  |  |  |
Equity loss from affiliates | $ | — |  |  | $ | — |  |  | $ | — |  |  | $ | — |
Depreciation | 9 |  |  | 105 |  |  | 10 |  |  | 124 |
Property, Plant and Equipment, Net by Geographic Area | Property, plant and equipment, net, by geographic area where located is as follows:
December 31 | 2021 |  | 2020 |  | 2019
United States | $ | 11,759 |  |  | $ | 10,394 |  |  | $ | 8,963 |
Europe, Middle East and Africa | 6,081 |  |  | 5,314 |  |  | 4,129 |
Asia Pacific (other than China and Japan) | 857 |  |  | 737 |  |  | 692 |
China | 220 |  |  | 216 |  |  | 174 |
Latin America | 199 |  |  | 169 |  |  | 180 |
Japan | 159 |  |  | 166 |  |  | 152 |
Other | 4 |  |  | 4 |  |  | 7 |
| $ | 19,279 |  |  | $ | 17,000 |  |  | $ | 14,297 |

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