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Acquisitions, Research Collaborations and License Agreements - Estimated Fair Value of Assets Acquired and Liabilities Assumed (Details)
$ in Millions
1 Months Ended 12 Months Ended
Apr. 01, 2019
USD ($)
Nov. 30, 2021
Dec. 31, 2021
USD ($)
Nov. 19, 2021
USD ($)
Dec. 31, 2020
USD ($)
Jan. 16, 2020
USD ($)
Dec. 31, 2019
USD ($)
Business Acquisition [Line Items]              
Goodwill     $ 21,264   $ 18,882   $ 18,069
Acceleron Pharma Inc.              
Business Acquisition [Line Items]              
Cash and cash equivalents       $ 340      
Investments       285      
In-process research and development (IPR&D)       6,380      
Products and product rights - Reblozyl (12 year useful life)       3,830      
Estimated useful life of intangible assets, acquired   12 years          
Deferred income tax liabilities       (1,832)      
Other assets and liabilities, net       89      
Total identifiable net assets       9,092      
Goodwill       2,422      
Consideration transferred       $ 11,514      
Acceleron Pharma Inc. | Measurement Input, Discount Rate              
Business Acquisition [Line Items]              
Present value discount rate       0.075      
Discount rate       0.060      
ArQule              
Business Acquisition [Line Items]              
Cash and cash equivalents           $ 145  
In-process research and development (IPR&D)           2,280  
Identifiable intangible assets           80  
Deferred income tax liabilities           (361)  
Other assets and liabilities, net           34  
Total identifiable net assets           2,178  
Goodwill           512  
Consideration transferred           $ 2,690  
ArQule | Measurement Input, Discount Rate              
Business Acquisition [Line Items]              
Present value discount rate           0.125  
Antelliq              
Business Acquisition [Line Items]              
Cash and cash equivalents $ 31            
Accounts receivable 73            
Inventories 93            
Property, plant and equipment 60            
Identifiable intangible assets 2,689            
Deferred income tax liabilities (589)            
Other assets and liabilities, net (82)            
Total identifiable net assets 2,275            
Goodwill 1,376            
Consideration transferred $ 3,651            
Antelliq | Measurement Input, Discount Rate              
Business Acquisition [Line Items]              
Present value discount rate 0.115            
Minimum              
Business Acquisition [Line Items]              
Estimated useful life of intangible assets     2 years        
Minimum | Antelliq              
Business Acquisition [Line Items]              
Estimated useful life of intangible assets 18 years            
Maximum              
Business Acquisition [Line Items]              
Estimated useful life of intangible assets     24 years        
Maximum | Antelliq              
Business Acquisition [Line Items]              
Estimated useful life of intangible assets 24 years