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Amount after amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.

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Sum of the carrying amounts as of the balance sheet date of all liabilities that are recognized. Liabilities are probable future sacrifices of economic benefits arising from present obligations of an entity to transfer assets or provide services to other entities in the future.

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Collaborative Arrangements - Narrative (Details) course in Thousands, $ in Millions	1 Months Ended			12 Months Ended
	Dec. 31, 2021 USD ($) course	Nov. 30, 2021 course	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($) course market country	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Other intangibles, net	$ 22,933			$ 22,933	$ 14,101
Amortization				$ 1,636	1,817	$ 1,695
Number of markets (more than) \| market				30
Number of low and middle income countries (more than) \| country				100
Supply Commitment to United States
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Quantity committed (in courses) \| course	3,100
Quantity delivered (in courses) \| course				888
Supply Commitment to Japan
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Quantity committed (in courses) \| course	1,600
Quantity delivered (in courses) \| course				200
Supply Commitment to United Kingdom
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Quantity committed (in courses) \| course		2,230
Quantity delivered (in courses) \| course				152
Supply Commitment to United Nations Children's Fund
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Quantity committed (in courses) \| course				3,000
License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Other intangibles, net	$ 3,368			$ 3,368	3,553
Lenvima \| License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Other intangibles, net	1,000			1,000
Adempas \| Licenses and other
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Intangible assets	806			806
Verquvo
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Amortization				153
Verquvo \| Licenses and other
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Intangible assets	68			68
Lynparza \| License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Other intangibles, net	1,100			1,100
Eisai
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
License option payment related to collaborative arrangement			$ 125
Eisai \| Lenvima \| Sales-Based Milestones
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments made to collaborative partner				200	500	50
Eisai \| Lenvima \| Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments accrued	600			600
Accrued regulatory approval milestone payment	25			25
Potential Future Milestone Payments Sales-Based	2,600			2,600
Potential Future Milestone Payments Regulatory	25			25
Eisai \| Lenvima \| Regulatory Milestones
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments made to collaborative partner				75	10
Bayer AG \| Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments accrued	400			400
Liabilities	400			400
Bayer AG \| Adempas \| Sales-Based Milestones
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments made to collaborative partner					375
AstraZeneca \| Lynparza \| Sales-Based Milestones
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments made to collaborative partner					550	200
AstraZeneca \| Lynparza \| Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments accrued	400			400
Potential Future Milestone Payments Sales-Based	2,700			2,700
Potential Future Milestone Payments Regulatory	$ 1,400			$ 1,400
AstraZeneca \| Lynparza \| Regulatory Milestones
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments made to collaborative partner					$ 160	$ 60