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Goodwill and Other Intangibles - Narrative (Details) $ in Millions	12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Apr. 01, 2019
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	$ 22,933	$ 14,101
Intangible asset impairment charge related to marketed product			$ 705
IPR&D impairment charges			172
Contingent consideration liability, changes in estimated fair value	57	83
Amortization expense for intangible assets	1,600	1,800	1,700
Estimated aggregate amortization expense, 2022	1,700
Estimated aggregate amortization expense, 2023	1,600
Estimated aggregate amortization expense, 2024	1,600
Estimated aggregate amortization expense, 2025	1,400
Estimated aggregate amortization expense, 2026	1,400
IPR&D
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	9,281	3,228
Zerbaxa
Intangible Assets Excluding Goodwill [Line Items]
Intangible asset impairment charge related to marketed product		1,600
Inventory write-down		120
Sivextro
Intangible Assets Excluding Goodwill [Line Items]
Intangible asset impairment charge related to marketed product			612
Animal Health
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	5,000
Adempas | Licenses and other
Intangible Assets Excluding Goodwill [Line Items]
Intangible assets	806
Verquvo | Licenses and other
Intangible Assets Excluding Goodwill [Line Items]
Intangible assets	68
COVID-19
Intangible Assets Excluding Goodwill [Line Items]
IPR&D impairment charges		90
Contingent consideration liability, changes in estimated fair value		(45)
IOmet Pharma Ltd
Intangible Assets Excluding Goodwill [Line Items]
IPR&D impairment charges			155
Contingent consideration liability, changes in estimated fair value			$ (11)
sotatercept | IPR&D
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	6,400
nemtabrutinib
Intangible Assets Excluding Goodwill [Line Items]
IPR&D impairment charges	275
nemtabrutinib | IPR&D
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	$ 2,000
nemtabrutinib | Measurement Input, Discount Rate | Valuation Technique, Discounted Cash Flow | Fair Value, Measurements, Recurring
Intangible Assets Excluding Goodwill [Line Items]
Discount rate	0.085
gefapixant | IPR&D
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	$ 832
Products and product rights
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	7,895	4,790
Products and product rights | Reblozyl
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	3,800
Products and product rights | Zerbaxa
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	478
Products and product rights | Gardasil/Gardasil 9
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	191
Products and product rights | Bridion
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	145
Products and product rights | Dificid
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	145
Products and product rights | Sivextro
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	138
Products and product rights | Simponi
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	101
Trade names
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	2,389	2,530
License
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	3,368	$ 3,553
License | Lynparza
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	1,100
License | Lenvima
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	1,000
Antelliq | Measurement Input, Discount Rate
Intangible Assets Excluding Goodwill [Line Items]
Discount rate				0.115
Antelliq | Trade names
Intangible Assets Excluding Goodwill [Line Items]
Other intangibles, net	$ 2,300

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