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Collaborative Arrangements - Financial Information (Details) - USD ($) $ in Millions | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sales | $ 14,593 | $ 11,402 | $ 30,494 | $ 22,029 |
Cost of sales | 4,216 | 3,104 | 9,596 | 6,303 |
Selling, general and administrative | 2,512 | 2,281 | 4,834 | 4,468 |
Research and development | 2,798 | 4,321 | 5,374 | 6,732 |
Payables included in Accrued and other liabilities | 23,168 |  | 23,168 |  | $ 23,872
Other current assets | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Receivables included in Other current assets | 300 |  | 300 |  | 271
Other current assets | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Receivables included in Other current assets | 247 |  | 247 |  | 200
Other current assets | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Receivables included in Other current assets | 144 |  | 144 |  | 114
Accounts Payable and Accrued Liabilities | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Payables included in Accrued and other liabilities | 12 |  | 12 |  | 415
Accounts Payable and Accrued Liabilities | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Payables included in Accrued and other liabilities | 25 |  | 25 |  | 625
Accounts Payable and Accrued Liabilities | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Payables included in Accrued and other liabilities | 74 |  | 74 |  | 472
Accounts Payable and Accrued Liabilities | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Payables included in Accrued and other liabilities | 683 |  | 683 |  | 283
Other Noncurrent Liabilities | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Payables included in Other Noncurrent Liabilities | 600 |  | 600 |  | $ 0
Revenue | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Alliance revenue - profit sharing | 299 | 256 | 574 | 489 |
Revenue | AstraZeneca | Collaborative Arrangement | Alliance revenue - Lynparza |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Alliance revenue - profit sharing | 275 | 248 | 541 | 475 |
Revenue | AstraZeneca | Collaborative Arrangement | Alliance revenue - Koselugo |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Alliance revenue - profit sharing | 24 | 8 | 33 | 14 |
Revenue | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Alliance revenue - profit sharing | 231 | 181 | 459 | 310 |
Revenue | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Alliance revenue - profit sharing | 98 | 74 | 170 | 149 |
Sales | 167 | 149 | 303 | 279 |
Revenue | Bayer AG | Collaborative Arrangement | Adempas |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Net sales by Merck | 63 | 74 | 124 | 129 |
Revenue | Bayer AG | Collaborative Arrangement | Verquvo |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Net sales by Merck | 6 | 1 | 9 | 1 |
Revenue | Ridgeback Biotherapeutics LP | Collaborative Arrangement | Lagevrio |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Sales | 1,177 | 0 | 4,424 | 0 |
Cost of sales | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cost of sales | 62 | 42 | 361 | 84 |
Amortization of intangible assets |  |  | 250 |  |
Cost of sales | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cost of sales | 53 | 47 | 106 | 94 |
Cost of sales | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cost of sales | 54 | 67 | 103 | 275 |
Amortization of intangible assets |  |  |  | 153 |
Cost of sales | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cost of sales | 622 | 6 | 2,338 | 52 |
Selling, general and administrative | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Selling, general and administrative | 46 | 43 | 90 | 83 |
Selling, general and administrative | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Selling, general and administrative | 42 | 31 | 73 | 54 |
Selling, general and administrative | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Selling, general and administrative | 42 | 34 | 65 | 51 |
Selling, general and administrative | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Selling, general and administrative | 30 | 4 | 65 | 7 |
Research and development | AstraZeneca | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development | 25 | 31 | 51 | 60 |
Research and development | Eisai | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development | 47 | 57 | 104 | 121 |
Research and development | Bayer AG | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development | 17 | 13 | 34 | 20 |
Research and development | Ridgeback Biotherapeutics LP | Collaborative Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development | $ 15 | $ 68 | $ 21 | $ 110 |

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