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Collaborative Arrangements - Narrative (Details)
course in Millions, $ in Millions
 1 Months Ended 3 Months Ended 6 Months Ended
Jan. 31, 2022
USD ($)
Mar. 31, 2021
USD ($)
Jun. 30, 2022
USD ($)
course
Mar. 31, 2022
USD ($)
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
market
course
Jun. 30, 2021
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Amortization           $ 1,163 $ 871
Number of markets (more than) | market           40  
Remaining minimum courses committed (in courses) | course     1.1     1.1  
Sales     $ 14,593   $ 11,402 $ 30,494 22,029
Operating Segments              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales     14,223   11,452 29,812 22,108
Operating Segments | Pharmaceutical              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales     12,756   9,980 26,863 19,218
Lynparza              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Amortization       $ 250      
Lynparza | Other Noncurrent Assets              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Finite-lived intangible assets     1,500     1,500  
Lenvima | Operating Segments | Pharmaceutical              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales     231   181 459 310
Lenvima | Other Noncurrent Assets              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Finite-lived intangible assets     920     920  
Verquvo | Other Intangible Assets              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Finite-lived intangible assets     60     60  
Adempas | Operating Segments | Pharmaceutical              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales     63   74 124 129
Adempas | Other Intangible Assets              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Finite-lived intangible assets     691     691  
Alliance Revenue - Reblozyl | Operating Segments | Pharmaceutical              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales     33   $ 0 86 $ 0
AstraZeneca | Sales-Based Milestones | Lynparza              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Probable contingent payments       600      
Liabilities       $ 600      
Milestone payments accrued but not yet paid     600     600  
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Lynparza              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales-based milestone payments           400  
Potential future sales-based milestone payments     2,100     2,100  
Potential future regulatory milestone payments     1,300     1,300  
Capitalized milestone payment           175  
Eisai              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
License option payment related to collaborative arrangement   $ 125          
Eisai | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Lenvima              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales-based milestone payments           600  
Potential future sales-based milestone payments     2,600     2,600  
Milestone payment accrued     $ 25     25  
Capitalized milestone payment           $ 25  
Bayer AG | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Sales-based milestone payments $ 400            
Bristol Myers Squibb | Licensing Agreements              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Royalty rate, deduction           0.50  
Royalties           $ 66  
Bristol Myers Squibb | Licensing Agreements | Sales-Based Milestones              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Contingent milestone payments collaborative arrangement           80  
Bristol Myers Squibb | Licensing Agreements | Regulatory Milestones              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Contingent milestone payments collaborative arrangement           $ 20  
Bristol Myers Squibb | Licensing Agreements | Minimum              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Royalty rate           20.00%  
Bristol Myers Squibb | Licensing Agreements | Maximum              
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]              
Royalty rate           24.00%