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Segment Reporting - Reconciliation of Segment Profits to Income before Taxes (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Segment Reporting Information [Line Items]
Profits	$ 4,487	$ 1,717	$ 9,348	$ 4,704
Interest income	15	9	22	20
Interest expense	(240)	(202)	(483)	(401)
Amortization			(1,163)	(871)
Depreciation			(895)	(749)
Research and development	(2,798)	(4,321)	(5,374)	(6,732)
Restructuring costs	(142)	(82)	(194)	(380)
Operating Segments
Segment Reporting Information [Line Items]
Profits	9,744	7,809	19,829	14,969
Operating Segments | Pharmaceutical segment
Segment Reporting Information [Line Items]
Profits	9,173	7,257	18,673	13,845
Operating Segments | Animal Health segment
Segment Reporting Information [Line Items]
Profits	571	552	1,156	1,124
Corporate, Non-Segment
Segment Reporting Information [Line Items]
Profits	260	(79)	454	(113)
Segment Reconciling Items
Segment Reporting Information [Line Items]
Interest income	15	9	22	20
Interest expense	(240)	(202)	(483)	(401)
Amortization	(463)	(357)	(1,163)	(871)
Depreciation	(431)	(332)	(809)	(673)
Research and development	(2,652)	(4,175)	(5,097)	(6,480)
Restructuring costs	(142)	(82)	(194)	(380)
Other unallocated, net	$ (1,604)	$ (874)	$ (3,211)	$ (1,367)

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