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Segment Reporting - Sales from Products (Details) - USD ($)
$ in Millions
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Segment Reporting Information [Line Items]        
Sales $ 14,959 $ 13,154 $ 45,453 $ 35,183
Revenue related to the sale of the marketing rights     156 191
U.S.        
Segment Reporting Information [Line Items]        
Sales 7,322 6,276 20,927 16,166
Int’l        
Segment Reporting Information [Line Items]        
Sales 7,637 6,878 24,526 19,017
Operating Segments        
Segment Reporting Information [Line Items]        
Sales 14,334 12,913 44,146 35,021
Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 7,095 6,137 20,544 15,974
Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 7,239 6,777 23,601 19,047
Corporate, Non-Segment        
Segment Reporting Information [Line Items]        
Sales 625 241 1,307 162
Corporate, Non-Segment | U.S.        
Segment Reporting Information [Line Items]        
Sales 227 139 383 192
Corporate, Non-Segment | Int’l        
Segment Reporting Information [Line Items]        
Sales 398 101 925 (30)
Pharmaceutical | Operating Segments        
Segment Reporting Information [Line Items]        
Sales 12,963 11,496 39,826 30,714
Pharmaceutical | Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 6,620 5,670 19,119 14,611
Pharmaceutical | Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 6,343 5,826 20,707 16,103
Pharmaceutical | Operating Segments | Keytruda        
Segment Reporting Information [Line Items]        
Sales 5,426 4,534 15,487 12,609
Pharmaceutical | Operating Segments | Keytruda | U.S.        
Segment Reporting Information [Line Items]        
Sales 3,331 2,580 9,307 7,108
Pharmaceutical | Operating Segments | Keytruda | Int’l        
Segment Reporting Information [Line Items]        
Sales 2,095 1,954 6,180 5,501
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza        
Segment Reporting Information [Line Items]        
Sales 284 246 825 721
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza | U.S.        
Segment Reporting Information [Line Items]        
Sales 144 129 427 371
Pharmaceutical | Operating Segments | Alliance revenue - Lynparza | Int’l        
Segment Reporting Information [Line Items]        
Sales 140 117 397 350
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima        
Segment Reporting Information [Line Items]        
Sales 202 188 660 498
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima | U.S.        
Segment Reporting Information [Line Items]        
Sales 142 114 426 287
Pharmaceutical | Operating Segments | Alliance revenue - Lenvima | Int’l        
Segment Reporting Information [Line Items]        
Sales 60 74 235 211
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl        
Segment Reporting Information [Line Items]        
Sales 39 0 124 0
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl | U.S.        
Segment Reporting Information [Line Items]        
Sales 32 0 87 0
Pharmaceutical | Operating Segments | Alliance Revenue - Reblozyl | Int’l        
Segment Reporting Information [Line Items]        
Sales 7 0 37 0
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9        
Segment Reporting Information [Line Items]        
Sales 2,294 1,993 5,428 4,144
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9 | U.S.        
Segment Reporting Information [Line Items]        
Sales 957 839 1,803 1,605
Pharmaceutical | Operating Segments | Gardasil/Gardasil 9 | Int’l        
Segment Reporting Information [Line Items]        
Sales 1,337 1,154 3,624 2,539
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax        
Segment Reporting Information [Line Items]        
Sales 668 661 1,716 1,626
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax | U.S.        
Segment Reporting Information [Line Items]        
Sales 532 537 1,337 1,255
Pharmaceutical | Operating Segments | ProQuad/M-M-R II/Varivax | Int’l        
Segment Reporting Information [Line Items]        
Sales 136 125 379 371
Pharmaceutical | Operating Segments | RotaTeq        
Segment Reporting Information [Line Items]        
Sales 256 227 644 593
Pharmaceutical | Operating Segments | RotaTeq | U.S.        
Segment Reporting Information [Line Items]        
Sales 154 135 427 364
Pharmaceutical | Operating Segments | RotaTeq | Int’l        
Segment Reporting Information [Line Items]        
Sales 102 92 218 229
Pharmaceutical | Operating Segments | Pneumovax 23        
Segment Reporting Information [Line Items]        
Sales 131 277 457 600
Pharmaceutical | Operating Segments | Pneumovax 23 | U.S.        
Segment Reporting Information [Line Items]        
Sales 68 181 280 354
Pharmaceutical | Operating Segments | Pneumovax 23 | Int’l        
Segment Reporting Information [Line Items]        
Sales 63 97 177 247
Pharmaceutical | Operating Segments | Vaqta        
Segment Reporting Information [Line Items]        
Sales 64 48 134 138
Pharmaceutical | Operating Segments | Vaqta | U.S.        
Segment Reporting Information [Line Items]        
Sales 27 32 72 80
Pharmaceutical | Operating Segments | Vaqta | Int’l        
Segment Reporting Information [Line Items]        
Sales 36 16 62 58
Pharmaceutical | Operating Segments | Bridion        
Segment Reporting Information [Line Items]        
Sales 423 369 1,244 1,096
Pharmaceutical | Operating Segments | Bridion | U.S.        
Segment Reporting Information [Line Items]        
Sales 233 181 665 545
Pharmaceutical | Operating Segments | Bridion | Int’l        
Segment Reporting Information [Line Items]        
Sales 190 188 579 551
Pharmaceutical | Operating Segments | Prevymis        
Segment Reporting Information [Line Items]        
Sales 114 96 310 270
Pharmaceutical | Operating Segments | Prevymis | U.S.        
Segment Reporting Information [Line Items]        
Sales 49 39 136 111
Pharmaceutical | Operating Segments | Prevymis | Int’l        
Segment Reporting Information [Line Items]        
Sales 64 57 174 159
Pharmaceutical | Operating Segments | Dificid        
Segment Reporting Information [Line Items]        
Sales 77 54 196 115
Pharmaceutical | Operating Segments | Dificid | U.S.        
Segment Reporting Information [Line Items]        
Sales 72 52 184 108
Pharmaceutical | Operating Segments | Dificid | Int’l        
Segment Reporting Information [Line Items]        
Sales 6 2 12 7
Pharmaceutical | Operating Segments | Primaxin        
Segment Reporting Information [Line Items]        
Sales 63 70 185 194
Pharmaceutical | Operating Segments | Primaxin | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 1 0
Pharmaceutical | Operating Segments | Primaxin | Int’l        
Segment Reporting Information [Line Items]        
Sales 63 69 185 194
Pharmaceutical | Operating Segments | Noxafil        
Segment Reporting Information [Line Items]        
Sales 62 64 180 197
Pharmaceutical | Operating Segments | Noxafil | U.S.        
Segment Reporting Information [Line Items]        
Sales 13 19 39 48
Pharmaceutical | Operating Segments | Noxafil | Int’l        
Segment Reporting Information [Line Items]        
Sales 49 45 141 149
Pharmaceutical | Operating Segments | Invanz        
Segment Reporting Information [Line Items]        
Sales 50 53 148 157
Pharmaceutical | Operating Segments | Invanz | U.S.        
Segment Reporting Information [Line Items]        
Sales 2 (2) 4 (2)
Pharmaceutical | Operating Segments | Invanz | Int’l        
Segment Reporting Information [Line Items]        
Sales 48 55 144 159
Pharmaceutical | Operating Segments | Cancidas        
Segment Reporting Information [Line Items]        
Sales 43 56 138 168
Pharmaceutical | Operating Segments | Cancidas | U.S.        
Segment Reporting Information [Line Items]        
Sales 1 1 5 4
Pharmaceutical | Operating Segments | Cancidas | Int’l        
Segment Reporting Information [Line Items]        
Sales 42 56 133 164
Pharmaceutical | Operating Segments | Zerbaxa        
Segment Reporting Information [Line Items]        
Sales 43 (2) 120 (11)
Pharmaceutical | Operating Segments | Zerbaxa | U.S.        
Segment Reporting Information [Line Items]        
Sales 24 (1) 64 (5)
Pharmaceutical | Operating Segments | Zerbaxa | Int’l        
Segment Reporting Information [Line Items]        
Sales 19 (1) 55 (6)
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo        
Segment Reporting Information [Line Items]        
Sales 88 100 258 248
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo | U.S.        
Segment Reporting Information [Line Items]        
Sales 85 73 244 222
Pharmaceutical | Operating Segments | Alliance revenue - Adempas/Verquvo | Int’l        
Segment Reporting Information [Line Items]        
Sales 3 27 14 26
Pharmaceutical | Operating Segments | Adempas        
Segment Reporting Information [Line Items]        
Sales 57 59 181 188
Pharmaceutical | Operating Segments | Adempas | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Adempas | Int’l        
Segment Reporting Information [Line Items]        
Sales 57 59 181 188
Pharmaceutical | Operating Segments | Lagevrio        
Segment Reporting Information [Line Items]        
Sales 436 0 4,859 0
Pharmaceutical | Operating Segments | Lagevrio | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 1,523 0
Pharmaceutical | Operating Segments | Lagevrio | Int’l        
Segment Reporting Information [Line Items]        
Sales 436 0 3,336 0
Pharmaceutical | Operating Segments | Isentress/Isentress HD        
Segment Reporting Information [Line Items]        
Sales 161 189 466 590
Pharmaceutical | Operating Segments | Isentress/Isentress HD | U.S.        
Segment Reporting Information [Line Items]        
Sales 68 77 196 222
Pharmaceutical | Operating Segments | Isentress/Isentress HD | Int’l        
Segment Reporting Information [Line Items]        
Sales 93 112 270 368
Pharmaceutical | Operating Segments | Belsomra        
Segment Reporting Information [Line Items]        
Sales 62 81 199 238
Pharmaceutical | Operating Segments | Belsomra | U.S.        
Segment Reporting Information [Line Items]        
Sales 20 23 60 56
Pharmaceutical | Operating Segments | Belsomra | Int’l        
Segment Reporting Information [Line Items]        
Sales 42 58 139 183
Pharmaceutical | Operating Segments | Simponi        
Segment Reporting Information [Line Items]        
Sales 173 203 540 619
Pharmaceutical | Operating Segments | Simponi | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Simponi | Int’l        
Segment Reporting Information [Line Items]        
Sales 173 203 540 619
Pharmaceutical | Operating Segments | Remicade        
Segment Reporting Information [Line Items]        
Sales 49 73 163 233
Pharmaceutical | Operating Segments | Remicade | U.S.        
Segment Reporting Information [Line Items]        
Sales 0 0 0 0
Pharmaceutical | Operating Segments | Remicade | Int’l        
Segment Reporting Information [Line Items]        
Sales 49 73 163 233
Pharmaceutical | Operating Segments | Januvia        
Segment Reporting Information [Line Items]        
Sales 717 852 2,252 2,445
Pharmaceutical | Operating Segments | Januvia | U.S.        
Segment Reporting Information [Line Items]        
Sales 332 365 958 997
Pharmaceutical | Operating Segments | Januvia | Int’l        
Segment Reporting Information [Line Items]        
Sales 385 487 1,294 1,448
Pharmaceutical | Operating Segments | Janumet        
Segment Reporting Information [Line Items]        
Sales 417 487 1,347 1,449
Pharmaceutical | Operating Segments | Janumet | U.S.        
Segment Reporting Information [Line Items]        
Sales 90 86 258 244
Pharmaceutical | Operating Segments | Janumet | Int’l        
Segment Reporting Information [Line Items]        
Sales 327 401 1,089 1,205
Pharmaceutical | Operating Segments | Other pharmaceutical        
Segment Reporting Information [Line Items]        
Sales 564 518 1,565 1,589
Pharmaceutical | Operating Segments | Other pharmaceutical | U.S.        
Segment Reporting Information [Line Items]        
Sales 244 210 616 637
Pharmaceutical | Operating Segments | Other pharmaceutical | Int’l        
Segment Reporting Information [Line Items]        
Sales 321 306 949 950
Animal Health | Operating Segments        
Segment Reporting Information [Line Items]        
Sales 1,371 1,417 4,320 4,307
Animal Health | Operating Segments | U.S.        
Segment Reporting Information [Line Items]        
Sales 475 467 1,425 1,363
Animal Health | Operating Segments | Int’l        
Segment Reporting Information [Line Items]        
Sales 896 951 2,894 2,944
Animal Health | Operating Segments | Livestock        
Segment Reporting Information [Line Items]        
Sales 829 864 2,486 2,503
Animal Health | Operating Segments | Livestock | U.S.        
Segment Reporting Information [Line Items]        
Sales 186 190 521 508
Animal Health | Operating Segments | Livestock | Int’l        
Segment Reporting Information [Line Items]        
Sales 643 675 1,965 1,996
Animal Health | Operating Segments | Companion Animals        
Segment Reporting Information [Line Items]        
Sales 542 553 1,834 1,804
Animal Health | Operating Segments | Companion Animals | U.S.        
Segment Reporting Information [Line Items]        
Sales 289 277 904 855
Animal Health | Operating Segments | Companion Animals | Int’l        
Segment Reporting Information [Line Items]        
Sales $ 253 $ 276 $ 929 $ 948