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Segment Reporting - Reconciliation of Segment Profits to Income before Taxes (Details) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Segment Reporting Information [Line Items]
Profits	$ 3,583	$ 5,266	$ 12,931	$ 9,970
Interest income	40	7	62	27
Interest expense	(244)	(196)	(727)	(597)
Amortization			(1,623)	(1,231)
Depreciation			(1,394)	(1,148)
Research and development	(4,399)	(2,445)	(9,773)	(9,177)
Restructuring costs	(94)	(107)	(288)	(487)
Operating Segments
Segment Reporting Information [Line Items]
Profits	10,105	9,111	29,935	24,079
Operating Segments | Pharmaceutical segment
Segment Reporting Information [Line Items]
Profits	9,590	8,606	28,263	22,450
Operating Segments | Animal Health segment
Segment Reporting Information [Line Items]
Profits	515	505	1,672	1,629
Corporate, Non-Segment
Segment Reporting Information [Line Items]
Profits	377	141	831	29
Segment Reconciling Items
Segment Reporting Information [Line Items]
Interest income	40	7	62	27
Interest expense	(244)	(196)	(727)	(597)
Amortization	(460)	(360)	(1,623)	(1,231)
Depreciation	(448)	(358)	(1,257)	(1,031)
Research and development	(4,277)	(2,312)	(9,374)	(8,775)
Restructuring costs	(94)	(107)	(288)	(487)
Other unallocated, net	$ (1,416)	$ (660)	$ (4,628)	$ (2,044)

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