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CONDENSED CONSOLIDATED STATEMENT OF CASH FLOWS - USD ($) $ in Millions | 6 Months Ended
--- | ---
Jun. 30, 2023 | Jun. 30, 2022
Cash Flows from Operating Activities |  |
Net (loss) income | $ (3,147) | $ 8,256
Adjustments to reconcile net (loss) income to net cash provided by operating activities: |  |
Amortization | 1,020 | 1,163
Depreciation | 874 | 895
(Income) loss from investments in equity securities, net | (274) | 991
Charge for the acquisition of Prometheus Biosciences, Inc. | 10,217 | 0
Charge for the acquisition of Imago BioSciences, Inc. | 1,192 | 0
Deferred income taxes | (632) | (600)
Share-based compensation | 314 | 257
Other | 5 | 799
Net changes in assets and liabilities | (4,526) | (2,698)
Net Cash Provided by Operating Activities | 5,043 | 9,063
Cash Flows from Investing Activities |  |
Capital expenditures | (1,972) | (2,113)
Purchases of securities and other investments | (587) | (705)
Proceeds from sales of securities and other investments | 785 | 374
Acquisition of Prometheus Biosciences, Inc., net of cash acquired | (10,705) | 0
Acquisition of Imago BioSciences, Inc., net of cash acquired | (1,327) | 0
Other | 4 | 194
Net Cash Used in Investing Activities | (13,802) | (2,250)
Cash Flows from Financing Activities |  |
Net change in short-term borrowings | 1,937 | 0
Proceeds from issuance of debt | 5,946 | 0
Payments on debt | (1,751) | (1,250)
Purchases of treasury stock | (487) | 0
Dividends paid to stockholders | (3,738) | (3,515)
Proceeds from exercise of stock options | 112 | 109
Other | (315) | (207)
Net Cash Provided by (Used in) Financing Activities | 1,704 | (4,863)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | (6) | (364)
Net (Decrease) Increase in Cash, Cash Equivalents and Restricted Cash | (7,061) | 1,586
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes restricted cash of $79 and $71 at January 1, 2023 and 2022, respectively, included in Other current assets) | 12,773 | 8,167
Cash, Cash Equivalents and Restricted Cash at End of Period (includes restricted cash of $52 and $78 at June 30, 2023 and 2022, respectively, included in Other current assets) | $ 5,712 | $ 9,753

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- Definition The cash outflow for purchases of and capital improvements on property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 805 -SubTopic 50 -Name Accounting Standards Codification -Section 25 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480060/805-50-25-1 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 805 -SubTopic 50 -Name Accounting Standards Codification -Section 30 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480027/805-50-30-1 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 805 -SubTopic 50 -Name Accounting Standards Codification -Section 30 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480027/805-50-30-2 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Name Accounting Standards Codification -Section 45 -Paragraph 13 -Subparagraph (c) -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-13 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Topic 946 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 3 -Subparagraph (SX 210.6-03(i)(1)) -Publisher FASB -URI https://asc.fasb.org//1943274/2147479886/946-10-S99-3 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 + Details
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- Definition Amount of cash inflow (outflow) from financing activities classified as other. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 230 -SubTopic 10 -Name Accounting Standards Codification -Section 45 -Paragraph 14 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-14 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Name Accounting Standards Codification -Section 45 -Paragraph 15 -SubTopic 10 -Topic 230 -Publisher FASB -URI https://asc.fasb.org//1943274/2147482740/230-10-45-15 + Details
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