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Consolidated Statement of Cash Flows - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash Flows from Operating Activities |  |  |
Net income | $ 17,133 | $ 377 | $ 14,526
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Amortization | 2,395 | 2,044 | 2,085
Depreciation | 2,104 | 1,828 | 1,824
Intangible asset impairment charges | 39 | 792 | 1,749
(Income) loss from investments in equity securities, net | (14) | (340) | 1,419
Charges for certain research and development asset acquisitions | 3,456 | 11,409 | 0
Deferred income taxes | (1,249) | (1,899) | (1,568)
Share-based compensation | 761 | 645 | 541
Other | 510 | 355 | 1,301
Net changes in assets and liabilities: |  |  |
Accounts receivable | (244) | (1,148) | (644)
Inventories | (835) | (816) | (161)
Trade accounts payable | 182 | (380) | (289)
Accrued and other current liabilities | (2,328) | 1,783 | (50)
Income taxes payable | 1,023 | 214 | 380
Noncurrent liabilities | (49) | 456 | (545)
Other | (1,416) | (2,314) | (1,473)
Net Cash Provided by Operating Activities | 21,468 | 13,006 | 19,095
Cash Flows from Investing Activities |  |  |
Capital expenditures | (3,372) | (3,863) | (4,388)
Purchases of securities and other investments | (519) | (955) | (1,204)
Proceeds from sale of Seagen Inc. common stock | 0 | 1,145 | 0
Proceeds from sales of securities and other investments | 377 | 1,658 | 721
Acquisition of Eyebiotech Limited, net of cash acquired | (1,344) | 0 | 0
Acquisition of Elanco Animal Health Incorporated aqua business | (1,303) | 0 | 0
Acquisition of Harpoon Therapeutics, Inc., net of cash acquired | (746) | 0 | 0
Acquisition of MK-1045 from Curon Pharmaceutical | (700) | 0 | 0
Acquisition of Prometheus Biosciences, Inc., net of cash acquired | 0 | (10,705) | 0
Acquisition of Imago BioSciences Inc., net of cash acquired | 0 | (1,327) | 0
Other | (127) | (36) | (89)
Net Cash Used in Investing Activities | (7,734) | (14,083) | (4,960)
Cash Flows from Financing Activities |  |  |
Payments on debt | (1,290) | (1,755) | (2,251)
Proceeds from issuance of debt | 3,599 | 5,939 | 0
Purchases of treasury stock | (1,306) | (1,346) | 0
Dividends paid to stockholders | (7,840) | (7,445) | (7,012)
Proceeds from exercise of stock options | 177 | 125 | 384
Other | (372) | (328) | (240)
Net Cash Used in Financing Activities | (7,032) | (4,810) | (9,119)
Effect of Exchange Rate Changes on Cash, Cash Equivalents and Restricted Cash | (293) | 23 | (410)
Net Increase (Decrease) in Cash, Cash Equivalents and Restricted Cash | 6,409 | (5,864) | 4,606
Cash, Cash Equivalents and Restricted Cash at Beginning of Year (includes $68, $79 and $71 of restricted cash at January 1, 2024, 2023 and 2022, respectively, included in Other current assets) | 6,909 | 12,773 | 8,167
Cash, Cash Equivalents and Restricted Cash at End of Year (includes $76, $68 and $79 of restricted cash at December 31, 2024, 2023 and 2022, respectively, included in Other current assets) | $ 13,318 | $ 6,909 | $ 12,773

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