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Taxes on Income - Reconciliation Between Effective Tax Rate and US Statutory Rate (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Amount |  |  |
U.S. statutory rate applied to income before taxes | $ 4,186 | $ 397 | $ 3,453
Differential arising from: |  |  |
Foreign earnings | (1,301) | (941) | (1,821)
Tax settlements and statute lapses | (557) | 0 | (10)
R&D tax credit | (202) | (214) | (117)
Inventory donations | (71) | (65) | (52)
State taxes | (39) | (117) | (110)
Charges for certain research and development asset acquisitions | 554 | 253 | 0
Valuation allowances | 54 | 70 | 108
Restructuring | 52 | 41 | 11
GILTI and the foreign-derived intangible income deduction | 29 | (80) | 462
Acquisition-related costs, including amortization | 18 | 42 | (3)
Acquisition of Prometheus | 0 | 2,139 | 0
Other | 80 | (13) | (3)
Taxes on income | $ 2,803 | $ 1,512 | $ 1,918
Tax Rate |  |  |
U.S. statutory rate applied to income before taxes | 21.00% | 21.00% | 21.00%
Differential arising from: |  |  |
Foreign earnings | (6.50%) | (49.80%) | (11.10%)
Tax settlements and statute lapses | (2.80%) | 0.00% | (0.10%)
R&D tax credit | (1.00%) | (11.30%) | (0.70%)
Inventory donations | (0.40%) | (3.50%) | (0.30%)
State taxes | (0.20%) | (6.20%) | (0.70%)
Charges for certain research and development asset acquisitions | 2.80% | 13.40% | 0.00%
Valuation allowances | 0.30% | 3.70% | 0.70%
Restructuring | 0.30% | 2.20% | 0.10%
GILTI and the foreign-derived intangible income deduction | 0.10% | (4.30%) | 2.80%
Acquisition-related costs, including amortization | 0.10% | 2.20% | 0.00%
Acquisition of Prometheus | 0.00% | 113.30% | 0.00%
Other | 0.40% | (0.70%) | 0.00%
Total, Tax Rate | 14.10% | 80.00% | 11.70%

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