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Collaborative Arrangements - Daiicho Sankyo - Narrative (Details)
$ in Millions
1 Months Ended 12 Months Ended
Aug. 31, 2024
USD ($)
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2022
USD ($)
Oct. 31, 2023
USD ($)
antibodyDrugConjugate
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Research and development   $ 17,938 $ 30,531 $ 13,548  
Daiichi Sankyo | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Number of antibody drug conjugates obtained right and obligations | antibodyDrugConjugate         3
Aggregate upfront payments due upon execution in collaborative arrangement         $ 4,000
Refundable upfront payments         1,000
Maximum aggregate contingent milestone payments, per product         $ 5,500
Research and development   $ 351 5,549    
Royalty percentage         5.00%
Upfront cash payment $ 170        
Daiichi Sankyo | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Ifinatamab Deruxtecan          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Refundable upfront payments         $ 500
Daiichi Sankyo | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Patritumab Deruxtecan          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Refundable upfront payments         500
Aggregate upfront payments due upon lapse of time         750
Daiichi Sankyo | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Patritumab Deruxtecan and Ralduotatug Deruxtecan          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Aggregate upfront payments due upon lapse of time     $ 1,500    
Daiichi Sankyo | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Raludotatug Deruxtecan          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]          
Aggregate upfront payments due upon lapse of time         $ 750
Liable contracted portion amount of research and development expenses to incur costs for, percentage         75.00%
Liable contracted portion amount of research and development expenses to incur costs for         $ 2,000