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Collaborative Arrangements - AstraZeneca PLC - Narrative (Details) - USD ($) | 6 Months Ended
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Jun. 30, 2025 | Jun. 30, 2024
Lynparza | Licenses and Other |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Finite-lived intangible assets | $ 1,000,000,000.0 |
Koselugo | Licenses and Other |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Finite-lived intangible assets | 44,000,000 |
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Sales based milestone payments | 700,000,000 |
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Lynparza |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Sales based milestone payments | 600,000,000 |
Eligible future contingent sales-based milestone payments (up to) | 2,000,000,000.0 |
Regulatory milestone payments |  | $ 245,000,000
Eligible future contingent regulatory milestone payments (up to) | 0 |
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Koselugo |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Sales based milestone payments | $ 100,000,000 |

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