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Collaborative Arrangements - AstraZeneca PLC - Narrative (Details) - USD ($)	6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024
Lynparza | Licenses and Other
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Finite-lived intangible assets	$ 1,000,000,000.0
Koselugo | Licenses and Other
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Finite-lived intangible assets	44,000,000
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sales based milestone payments	700,000,000
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Lynparza
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sales based milestone payments	600,000,000
Eligible future contingent sales-based milestone payments (up to)	2,000,000,000.0
Regulatory milestone payments		$ 245,000,000
Eligible future contingent regulatory milestone payments (up to)	0
AstraZeneca | Collaborative Arrangement, Transaction with Party to Collaborative Arrangement | Koselugo
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sales based milestone payments	$ 100,000,000

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 808
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-Name Accounting Standards Codification
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Amount after amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 350
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 926
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