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Revenue (Disaggregation of Revenue by Product) (Details) - USD ($) $ in Millions | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Disaggregation of Revenue [Line Items] |  |  |
Revenues | $ 28,318.4 | $ 24,539.8 | $ 22,319.5
U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 16,811.0 | 14,229.3 | 12,722.6
Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 11,507.4 | 10,310.5 | 9,596.8
Diabetes | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 8,719.3 | 7,909.1 | 7,529.5
Diabetes | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 4,468.8 | 3,925.3 | 3,602.6
Trulicity® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 4,914.4 | 3,835.9 | 3,155.2
Trulicity® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,557.6 | 1,232.2 | 972.7
Humalog® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,320.7 | 1,485.6 | 1,669.7
Humalog® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,132.3 | 1,140.3 | 1,151.0
Humulin® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 832.9 | 866.4 | 879.7
Humulin® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 389.6 | 393.2 | 410.4
Jardiance® |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,490.8 | 1,153.8 | 944.2
Jardiance® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 807.3 | 620.8 | 565.9
Jardiance® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 683.5 | 533.0 | 378.3
Basaglar® |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 892.5 | 1,124.4 | 1,112.6
Basaglar® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 588.3 | 842.3 | 876.2
Basaglar® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 304.2 | 282.1 | 236.3
Trajenta® |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 372.5 | 358.5 | 590.6
Trajenta® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 82.1 | 95.6 | 224.8
Trajenta® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 290.4 | 263.0 | 365.8
Other Diabetes | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 173.6 | 162.5 | 158.0
Other Diabetes | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 111.2 | 81.5 | 88.1
Oncology | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 3,028.8 | 2,792.1 | 2,608.5
Oncology | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 2,712.5 | 2,527.2 | 2,005.9
Alimta® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,233.9 | 1,265.3 | 1,219.5
Alimta® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 827.5 | 1,064.7 | 896.4
Verzenio® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 834.9 | 618.2 | 454.8
Verzenio® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 515.0 | 294.4 | 124.9
Cyramza® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 358.1 | 381.9 | 335.3
Cyramza® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 674.8 | 650.8 | 589.9
Erbitux® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 481.8 | 480.1 | 487.9
Erbitux® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 66.4 | 56.3 | 55.4
Tyvyt® |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 418.1 | 308.7 | 134.0
Tyvyt® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 0.0 | 0.0 | 0.0
Tyvyt® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 418.1 | 308.7 | 134.0
Other Oncology | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 120.1 | 46.6 | 111.0
Other Oncology | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 210.7 | 152.3 | 205.3
Immunology | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,881.8 | 1,372.3 | 1,059.0
Immunology | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,479.0 | 1,089.6 | 734.3
Taltz® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,542.4 | 1,288.5 | 1,016.8
Taltz® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 670.4 | 500.0 | 349.6
Olumiant® |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,115.1 | 638.9 | 426.9
Olumiant® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 324.1 | 63.8 | 42.2
Olumiant® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 791.0 | 575.0 | 384.7
Other Immunology | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 15.3 | 20.0 | 0.0
Other Immunology | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 17.6 | 14.6 | 0.0
Neuroscience | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 614.8 | 487.3 | 356.5
Neuroscience | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,283.7 | 1,344.0 | 1,366.4
Cymbalta® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 38.7 | 42.1 | 49.6
Cymbalta® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 542.8 | 725.6 | 675.8
Emgality® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 434.5 | 325.9 | 154.9
Emgality® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 142.7 | 37.0 | 7.7
Zyprexa® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 39.6 | 46.1 | 41.0
Zyprexa® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 390.7 | 360.5 | 377.6
Other Neuroscience | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 102.0 | 73.2 | 111.0
Other Neuroscience | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 207.5 | 220.9 | 305.3
Other | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 2,566.4 | 1,668.4 | 1,169.1
Other | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,563.5 | 1,424.4 | 1,887.7
COVID-19 Antibodies | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 1,978.0 | 850.0 | 0.0
COVID-19 Antibodies | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 261.4 | 21.2 | 0.0
Forteo® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 441.6 | 510.3 | 645.5
Forteo® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 360.3 | 536.0 | 759.1
Cialis® | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 10.6 | 61.8 | 231.7
Cialis® | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 707.9 | 545.4 | 658.8
Other | U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | 136.1 | 246.4 | 291.9
Other | Outside U.S. |  |  |
Disaggregation of Revenue [Line Items] |  |  |
Revenues | $ 233.9 | $ 321.8 | $ 469.7

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