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Property and Equipment (Tables)
12 Months Ended
Dec. 31, 2021
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment
At December 31, property and equipment consisted of the following:
20212020
Land$258.7 $226.8 
Buildings7,588.1 7,326.1 
Equipment8,937.2 8,560.9 
Construction in progress2,177.8 2,138.8 
18,961.8 18,252.6 
Less accumulated depreciation(9,976.7)(9,570.7)
Property and equipment, net$8,985.1 $8,681.9 
Depreciation expense related to property and equipment was as follows:
202120202019
Depreciation expense$787.0 $765.2 $814.7 
Long-lived Assets by Geographic Areas
The following table summarizes long-lived assets by geographical area:
20212020
Long-lived assets(1):
U.S. and Puerto Rico$6,620.0 $6,113.6 
Ireland1,702.3 1,786.9 
Other foreign countries1,691.0 1,747.7 
Long-lived assets$10,013.3 $9,648.2 
(1) Long-lived assets consist of property and equipment, net, operating lease assets, and certain other noncurrent assets.